Leitender Direktor
| Prof. Dr. Gunter Fischer |
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Curriculum vitae
Persönliche Angaben:
| Geburtstag und Geburtsort: |
23. Mai 1943 in Altenburg |
| Familienstand: |
verheiratet, Vater von drei Kindern |
| Nationalität: |
deutsch |
Ausbildung:
| 1949 - 1962 |
Grundschule, Oberschule, Berufsausbildung in den Leunawerken Merseburg; Facharbeiter der chemischen Produktion |
| 1962 - 1967 |
Martin-Luther-Universität Halle-Wittenberg, Institut für Organische Chemie (Prof. Wolfgang Langenbeck); Abschluss: Diplom |
| 1967 - 1971 |
Martin-Luther-Universität Halle-Wittenberg, Institut für Biochemie; Doktorand unter Prof. Alfred Schellenberger; Abschluss: Dr. rer. nat. |
| 1979 |
Habilitation und Lehrbefähigung (facultas docendi) in Biochemie |
Positionen:
| 1971 - 1987 | Martin-Luther-Universität Halle-Wittenberg, Fachbereich Biologie; unabhängiger Wissenschafler und Lehrassistent, festangestellter Dozent |
| 1987 - 1988 | Wissenschaftler am Biotechnischen Institut des Pharmazeutischen Kombinats GERMED in Berlin |
| 1989 - 1990 | Leiter des Fachbereiches Biochemie an der Martin-Luther-Universität Halle-Wittenberg |
| 1990 | Gastprofessor am Institut für physiologische Chemie an der Universität Würzburg |
| 1992 - 1997 | Gruppenleiter der Max-Planck-Arbeitsgruppe "Enzymologie der Peptidbindung" |
| seit 1992 | Lehrstuhlinhaber und Professor für Molekulare Biochemie am Institut für Biochemie und Biotechnologie an der Martin-Luther-Universität Halle-Wittenberg |
| seit 1997 | Leitender Direktor der "Max-Planck-Forschungsstelle für Enzymologie der Proteinfaltung" |
Berufliche Aktivitäten:
| 1992 - 2000 | Gewähltes Mitglied des Prüfungsausschusses für Biochemie der Deutschen Forschungsgemeinschaft |
| 1991 - 2002 | Ständiges Mitglied des Forschungsausschusses des Deutschen Verbandes der Chemischen Industrie, Fonds der Chemischen Industrie (VCI) |
| 1996 - 1999 | Komiteemitglied und Vizepräsident der Gesellschaft der Deutschen Chemiker (GDCh) |
| 1996 - 1998 | Gewähltes Mitglied des Senats der Martin-Luther-Universität Halle-Wittenberg |
| 1992 - 1995 | Deutsches Ausschussmitglied des HFSPO Grant Review Committee |
| seit 2000 | Vizepräsident der Nationalen Akademie der Wissenschaften Leopoldina |
| seit 1999 | Wissenschaftliches Mitglied der Max-Planck-Gesellschaft |
| seit 1994 | Beratender Redakteur des Journals "Biological Chemistry" |
| seit 1994 | Ad-hoc-Gutachter für verschiedene große Unternehmen (Volkswagenstiftung, Boehringer Ingelheim Fonds, Ministerium für Bildung und Forschung, Fonds der Chemischen Industrie) |
| seit 1994 | Ad-hoc-Gutachter für verschiedene Journale (Cell, Science, J. Amer. Chem. Soc., Eur. J. Biochemistry, Mol. Microbiol. FEBS-Lett., Biochem. J., EMBO J., J. Biol. Chem., J. Mol. Biol., Angew. Chemie) |
Auszeichnungen:
- Vollmitglied der Nationalen Akademie der Wissenschaften Leopoldina
- Vollmitglied der Berlin-Brandenburg-Akademie der Wissenschaften
- Gottfried-Wilhelm-Leibniz-Preis der Deutschen Forschungsgemeinschaft (DFG) (1993)
- Karl-Lohmann-Medaille der Biochemischen Gesellschaft der DDR
- Dozentenstipendium des Fonds der Chemischen Industrie (1990)
- Boehringer-Ingelheim Vortragsreise (1991)
- Fritz-Lipmann Ehrenvortrag der GBM (2002)
- Max-Bergmann-Medaille der Max-Bergmann-Gesellschaft (2002)
Publikationen
G. Oehme, G. Fischer & A. Schellenberger IR-spektroskopische Untersuchungen der Stereochemie und Energieübertragung in intramolekularen H-Brücken substituierter Phenylglyoxylsäuren Chem. Ber. 100, 425-437 (1967)
A. Schellenberger & G. Fischer Säure- und Metallionenkatalyse bei der Jodierung von Brenztraubensäuredialkylamiden Z. Chem. 8, 460-461 (1968)
G. Hübner, G. Fischer & A. Schellenberger Über den Einfluß von Carbonylverbindungen auf die Geschwindigkeit der Hefe-PDC Reaktion Z. Chem. 10, 436-437 (1970)
G. Fischer, G. Oehme & A. Schellenberger Beziehungen zwischen Struktur und UV-Spektren von alpha-Ketosäuren und verwandten alpha-Dicarbonylverbindungen Tetrahedron 27, 5683-5695 (1971)
G. Nafe, G. Hübner, G. Fischer, H. Neef & A. Schellenberger Hinweise auf Konformationsänderungen der Proteinkomponente beim Rekombinations- und Regulationsmechanismus der Hefe-PDC Acta Biol. Med. Germ. 29, 581-594 (1972)
G. Fischer & A. Schellenberger Kinetik der Enolisierung einiger Brenztraubensäureamide Tetrahedron 28, 4113-4123 (1972)
G. Fischer, G. Küllertz & A. Schellenberger Mechanismus der Enolisierung einiger Brenztraubensäureamide Tetrahedron 29, 4313-4320 (1973)
H. Lehmann, G. Fischer, G. Hübner, K.-D. Kohnert & A. Schellenberger The Influence of Steric and Electronic Parameters on the Substrate Behaviour of alpha-Oxo Acids to Yeast Pyruvate Decarboxylase Eur. J. Biochem. 32, 83-87 (1973)
G. Fischer & A. Schellenberger Self-association and Intramolecular Hydrogen Bonding of Monosubstituted Pyruvamides Tetrahedron Lett. 1974, 3307-3310 (1974)
10. G. Hübner, H. Neef, G. Fischer & A. Schellenberger Kinetischer N-15 Isotopieeffekt als direkter Beweis für die Beteiligung der Aminogruppe von Thiaminpyrophosphat an der enzymatischen Decarboxylierung von alpha-Ketosäuren Z. Chem. 15, 221 (1975)
G. Küllertz, G. Fischer & A. Barth Sekundäre D-Isotopieeffekte bei der Hydrolyse von 4-Nitroacetanilid Tetrahedron 32, 759-761 (1976)
G. Fischer, G. Küllertz & A. Schellenberger Sekundäre thermodynamische und kinetische Deuterium- Isotopieeffekte bei nucleophilen Additionsreaktionen an die Carbonylgruppe von Pyruvamid Tetrahedron 32, 1503-1505 (1976)
D. R. Petzold & G. Fischer H-1 nmr spektroskopische Untersuchungen des Systems Thiamin/ Mg2+/Pyruvat in Wasser Studia biophysica 54, 53-56 (1976)
G. Fischer, G. Küllertz, A. Barth & R. Rashid Mechanismus der basischen Hydrolyse von alpha- Aminosäureaniliden Z. Chem. 17, 380-381 (1977)
G. Küllertz, G. Fischer & A. Barth Beiträge zum Katalysemechanismus der Dipeptidyl-peptidase IV Acta Biol. Med. Germ. 37, 559-567 (1978)
G. Fischer, G. Küllertz & A. Barth Mechanismus der basischen Hydrolyse von Oligopeptid-4-nitroaniliden Tetrahedron 34, 2123-2129 (1978)
B. Wolf, G. Fischer und A. Barth Kinetische Untersuchungen an der Dipeptidyl-peptidase IV Acta Biol. Med. Germ. 37, 409-420 (1978)
A. Barth, H. Mager, G. Fischer, K. Neubert & G. Schwarz Struktur-Aktivitäts-Beziehungen bei der enzymatischen Hydrolyse von Dipeptid-arylamiden durch die DP IV Acta Bio. Med. Germ. 39, 1129-1142 (1980)
G. Fischer, G. Schönberner & G. Küllertz Untersuchungen zur Bestimmung der Lipaseaktivität mit titrimetrischen und turbidometrischen Methoden Zbl. Pharm. 120, 1233-1240 (1981)
20. G. Küllertz, G. Fischer & H. Schönberner Einfache titrimetrische Bestimmung der Serumlipase mit der pH-Stat Technik Z. Med. Labor Diagn. 22, 123-128 (1981)
B. Hartrodt, K. Neubert, G. Fischer, U. Demuth, T. Yoshimoto & A. Barth Degradation of ß-Casomorphin-5 by Proline-specific Endopeptidase and Post-proline Cleaving Enzyme Pharmazie 37, 72-73 (1982)
B. Hartrodt, K. Neubert, G. Fischer, H. Schulz & A. Barth Synthese und enzymatischer Abbau von ß-Casomorphin-5 Pharmazie 37, 165-169 (1982)
D. R. Petzold, G. Hübner, G. Fischer, H. Neef & A. Schellenberger H-1 nmr spektroskopische Untersuchungen zur Reaktivität des 2-H Atoms von TPP und Derivaten sowie von deren Komplexen Studia biophysica 87, 15-21 (1982)
G. Fischer, M. Sieber & A. Schellenberger The Carbonyl Reactivity of 3-Bromopyruvate and Related Compounds Bioorg. Chem. 11, 478-484 (1982)
G. Fischer, J. Heins & A. Barth The Conformation Around the Peptide Bond Between the P1 and P2 -Position is Important for the Catalytic Activity of Some Proline-specific Proteases Biochim. Biophys. Acta 742, 452-462 (1983)
G. Fischer, H.-U. Demuth & A. Barth Diacylhydroxylamines as Enzyme-activated Inhibitors for Serine Proteases Pharmazie 38, 249-250 (1983)
W. Kallenbach, G. Küllertz & G. Fischer Untersuchungen zur Bestimmung von Dipeptidyl Peptidase-Aktivitäten im Liquor Cerebrospinalis Psych. Neurol. Med. Psychol. (Leipzig) 36, 295-302 (1984)
W. Geserick, G. Küllertz, W. Keil, G. Fischer & M. Nagy Untersuchungen zum spurenkundlichen Nachweis von Sperma mittels DP IV Kriminalistik und forens. Wiss. 56, 66-69 (1984)
G. Fischer, C. Mech & H. Bang Nachweis einer Enzymkatalyse für die cis/trans Isomerisierung der Peptidbindung in prolinhaltigen Peptiden Biomed. Biochim. Acta 43, 1101-1111 (1984)
30. G. Fischer, H. Bang, E. Berger und A. Schellenberger Conformational Specificity of Chymotrypsin Toward Proline Containing Substrates Biochim. Biophys. Acta 791, 87-97 (1984)
R. L. Stein, H. Fujihara, D. M. Quinn, G. Fischer, G. Küllertz, A. Barth & R. L. Schowen Transition State Structural Features for Anilide Hydrolysis from ß-Deuterium Isotope Effects J. Am. Chem. Soc. 106, 1457-1461 (1984)
G. Fischer und H. Bang The Refolding of Urea-denatured Ribonuclease A is Catalyzed by Peptidyl Prolyl cis/trans Isomerase Biochim. Biophys. Acta 828, 39-42 (1985)
E. Berger, K. Neubert, G. Fischer & A. Barth Synthese des N-terminalen Hexapeptides Met-Ala-Ser-Pro-Phe-Ala, einer Signalsequenz des Leukocyten-Interferons Z. Chem. 25, 179-180 (1985)
G. Küllertz, A. Barth & G. Fischer Die Bestimmung der DP IV in biologischen Materialien J. Clin. Chem. Clin. Biochem. 24, 551-558 (1986)
G. Küllertz, M. Nagy, G. Fischer und A. Barth Isolierung und Characterisierung der DP IV aus humanen Seminalplasma Biomed. Biochim. Acta 45, 291-303 (1986)
W. Kallenbach, G. Küllertz, G. Fischer & A. Barth Die Validität der postprolin-spaltenden Aktivitäten im Liquor cerebrospinalis für die neurologisch-psychatrische Diagnostik Psychiat. Neurol. Med. Psychol. (Leipzig) 38, 456-463 (1986)
W. Kallenbach, G. Küllertz & G. Fischer DP IV -Aktivitäten in Hirnarealen und Nervengewebe des Menschen Pharmazie 41, 819 (1986)
K. Lang, F. X. Schmid & G. Fischer Catalysis of Protein Folding by Prolyl Isomerases Nature 329, 268-270 (1987)
E. Berger, G. Fischer, K. Neubert & A. Barth Stepwise Degradation of the Hexapeptide Met-Ala-Ser-Pro-Phe-Ala by Dipeptidyl Peptidase IV Biomed. Biochim. Acta 46, 671-676 (1987)
40. S. Flatau, G. Fischer, E. Kleinpeter & A. Schellenberger P-31 Investigations on Free and Enzyme-bound Thiamine-pyrophosphate FEBS Lett. 233, 379-382 (1988)
G. Fischer, S. Flatau, A. Schellenberger & A. Zschunke C-13 NMR Investigations of the Structure of alpha-Keto Acids in Aqueous Solutions J. Org. Chem. 53, 214-216 (1988)
H. U. Demuth, R. Baumgrass, C. Schaper, G. Fischer & A. Barth DP IV-Inactivation with N-Peptidyl-O-Aroyl Hydroxylamines J. Enzyme Inhibition 2, 129-142 (1988)
G. Fischer Trends in Protease Inhibition Natural Prod. Reports 465-495 (1988)
G. Fischer, B. Wittmann-Liebold, K. Lang, T. Kiefhaber & F. X. Schmid Cyclophilin and Peptidyl-Prolyl cis/trans Isomerase are Probably Identical Proteins Nature 337, 476-478 (1989)
G. Küllertz, W. Kallenbach, Gabriele Küllertz & G. Fischer Post-Prolin Hydrolyseaktivitäten im Liquor Cerebrospinalis Z. Med. Lab. Diagn. 30, 273-280 (1989)
G. Fischer, E. Berger & H. Bang Kinetic ß-Deuterium Isotopic Effects Suggest a Covalent Mechanism for the Protein Folding Enzyme Peptidyl-Prolyl cis/trans Isomerase FEBS Lett. 250, 267-270 (1989)
H.-U. Demuth, G. Fischer, A. Barth & R. L. Schowen N-O bond Fission as the Rate Determining Step in the Aqueous Conversion of N-Peptidyl-O-4-Nitrobenzoyl Hydroxylamines to p-Nitrobenzoic Acid and Peptidyl Hydroxamic Acid J. Org. Chem. 54, 5880-5883 (1989)
G. Küllertz, W. Kallenbach, G. Küllertz & G. Fischer Post-Prolin Hydrolyseaktivitäten im Liquor Cerebrospinalis Z. med. Lab. Diagn. 30, 273-280 (1989)
G. Fischer & F. X. Schmid The Mechanism of Protein Folding. Implications of In-Vitro Refolding Models for the de-novo Protein Folding and Translocation in the Cell Biochemistry 29, 2205-2212 (1990)
50. E. R. Schönbrunner, S. Mayer, M. Tropschug, G. Fischer, N. Takahashi & F. X. Schmid Catalyis of Protein Folding by Cyclophilins from Different Species is Highly Conserved J. Biol. Chem. 266, 3630-3635 (1990)
F. Janowski, G. Fischer, W. Urbaniak, Z. Foltynowicz & B. Marciniec Aminopropylsilane Treatment of the Surface of Porous Glasses Suitable for Enzyme Immobilisation J. Chem. Tech. Biotechnol. 51, 263-273 (1991)
D. Hübner, B. Hartrodt, E. Kleinpeter, D. Ströhl, W. Brandt, H. Schinke, M. Wahab, & G. Fischer Conformational Analysis of the Tetrapeptide Pro-D-Phe-Pro-Gly in Aqueous Solution Biochem. Biophys. Res. Commun. 177, 271-278 (1991)
D. Hübner, T. Drakenberg, S. Forsen & G. Fischer PPIase Activity as Studied by Dynamic Proton NMR FEBS Lett. 284, 79-81 (1991)
H. Bang & G. Fischer Slow Conformational Changes in Protein Folding can be Accelerated by Enzymes Biomed. Biochim. Acta 50, S137-S142 (1991)
G. Fischer, H. Bang, B. Ludwig, K. Mann & J. Hacker Mip Protein of Legionella pneumophila Exhibits Peptidyl Prolyl cis/trans Isomerase Activity Mol. Microbiol. 6, 1375-1383 (1992)
G. Willimsky, H. Bang, G. Fischer & M. A. Marahiel Characterization of cspB, a Bacillus subtilis Inducible Cold Shock Gene Affecting Cell Viability at Low Temperatures J. Bacteriol. 174, 6326-6335 (1992)
M. Herrler, H. Bang, K. Brune, G. Fischer & M. A. Marahiel Peptidyl Prolyl cis/trans Isomerase from Bacillus subtilis: A Prokaryotic Enzyme that is Highly Sensitive to Cyclosporin A FEBS Lett. 309, 231-234 (1992)
B. Hartrodt, H. Schinke, D. Hübner, G. Fischer & K. Neubert Synthesis, Conformation and Pharmacology of des-Tyr1 -ß-Casomorphin-5 Analogues Peptides 661-662 (1992)
D. Kern, T. Drakenberg, M. Witström, S. Forsen, H. Bang & G. Fischer The cis/trans Interconversion of the Calcium Regulating Hormone Calcitonin is Catalyzed by Cyclophilin FEBS Lett. 323, 198-202 (1993)
60. J. Hacker, M. Ott, E. Wintermeyer, B. Ludwig & G. Fischer Analysis of Virulence Factors of L. pneumophila Zbl. Bakter. 278, 348-358 (1993)
J. Hacker & G. Fischer Immunophilins-Structure,Function Relationship Mol. Microbiol. 10, 445-456 (1993)
G. Fischer About PPIases and their Inhibitors Angew.Chem. 106, 1479-1501 (1994); Angew. Chem. Int. Ed. Engl. 33, 1415-1436 (1994)
M. Schutkowski, K. Neubert & G. Fischer Influence on Proline-specific Enzymes of a Substrate- Containing the Thionoprolyl Peptide Bond Eur. J. Biochem. 221, 455-461 (1994)
B. Ludwig, J. Rahfeld, B. Schmidt, K. Mann, E. Wintermeyer, G. Fischer & J. Hacker Characterization of Mip Proteins of Legionella pneumophila FEMS Microbiol. Lett. 118, 23-30(1994)
S. Meyer, A. Jabs, M. Schutkowski & G. Fischer Separation of cis/trans Isomers of a Prolyl Peptide Bond by Capillary Zone Electrophoresis Electrophoresis 15, 1151-1157 (1994)
G. Küllertz & G. Fischer Influence of Additives on Resolution and Focusing Efficiency in Free Flow Isoelectric Focusing J. Chromatography A 684, 329-341 (1994)
G. Küllertz, S. Meyer & G. Fischer Differentation by Preparative Free Flow IEF of Cyclosporin A Inhibitable Peptidyl-Prolyl cis/trans Isomerases of Human Erythrocytes Electrophoresis 15, 960-967 (1994)
J. Rahfeld, A. Schierhorn, K. Mann & G. Fischer A Novel Peptidyl-Prolyl cis/trans Isomerase from Escherichia coli FEBS Lett. 343, 65-69 (1994)
J. Hacker, M. Ott, B. Ludwig, E. Wintermeyer, J. Rahfeld, G. Fischer, B. Jain & M. Tully Molecular Studies on Toxin Production and Other Virulence Features of Legionella pneumophila Zbl. Bakt. Suppl. 24, 33-42 (1994)
70. G. Kern. D. Kern, F. X. Schmid & G. Fischer Reassessment of the Putative Chaperon Function of Prolyl cis/trans Isomerases FEBS Lett. 348, 145-148(1994)
B. Schmidt, J. Rahfeld, A. Schierhorn, B. Ludwig, J. Hacker & G. Fischer A Homodimer Represents an Acive Species of the Peptidyl-Prolyl cis/trans Isomerase FKBP25mem from Legionella pneumophila FEBS Lett. 352, 185-190 (1994)
J.-U. Rahfeld, K. P. Rücknagel, B. Schelbert, B. Ludwig, J. Hacker, K. Mann & G. Fischer Confirmation of the Existence of a Third Family Among Peptidyl-Prolyl cis/trans Isomerases: Amino Acid Sequence and Recombinant Production of Parvulin FEBS Lett.352, 180-184 (1994)
T. Zarnt, K. Lang, H. Burtscher & G. Fischer Time-dependent Inhibition of Peptidyl-Prolyl cis/trans Isomerases by FK506 is Probably due to cis/trans Isomerization of the Inhibitors Imide Bond Biochem. J. 305, 159-164 (1995)
G. Kern, D. Kern, F. X. Schmid & G. Fischer A Kinetic Analysis of the Folding of Human Carbonic Anhydrase II and its Catalysis by Cyclophilin J. Biol. Chem. 270, 740-745 (1995)
B. Schmidt, G. Fischer, S. König, D. Svergun, V. Volkov & M. H. J. Koch Small-angle X-ray Solution Scattering Study on the Dimerization of the FKBP25mem from Legionella pneumophila FEBS Lett. 372, 169-172 (1995)
G. Stoller, K. P Rücknagel, K. H. Nierhaus, F. X. Schmid, G. Fischer & J.-U. Rahfeld A Ribosome-associated Peptidyl-Prolyl cis/trans Isomerase Identified as the Trigger Factor EMBO J. 14, 4939-4948 (1995)
D. Kern, G. Kern, G. Scherer, G. Fischer & T. Drakenberg A Kinetic Analysis of Cyclophilin-catalyzed Prolyl cis/trans Isomerization by Dynamic NMR Spectroscopy Biochemistry 34, 13594-13602 (1995)
M. Schutkowski, S. Wöllner & G. Fischer Inhibition of Peptidyl-Prolyl cis/trans Isomerase Activity by Substrate-analog Structures: Thioxo tetrapeptide-4-nitroanilides Biochemistry 34, 13016-1326 (1995)
E. Wintermeyer, B. Ludwig, M. Steinert, B. Schmidt, G. Fischer & J. Hacker Influence of Site-specifically Altered Mip Proteins on Intracellular Survival of Legionella pneumophila in Eukariotic Cells Infect. Immun. 63, 4576-4583 (1995)
80. W. Steffan, M. Schutkowski & G. Fischer Synthesis of Chromogenic Proline-containing Glycopeptides J. Chem. Soc., Chem. Commun. 313-314 (1996)
J.-U. Rahfeld, K. P. Rücknagel, G. Stoller, S. M. Horne, A. Schierhorn, K. D. Young & G. Fischer Isolation and Amino Acid Sequence of a New 22kDa FKBP-like Peptidyl-Prolyl cis/trans Isomerase of E. coli: Similarity to Mip-like Proteins of Pathogenic Bacteria J. Biol. Chem. 36, 22130-22138 (1996)
G. Stoller, T. Tradler, K. P. Rücknagel, J.-U. Rahfeld & G. Fischer An 11.8 kDa Proteolytic Fragment of the E. coli Trigger Factor Represents the Domain Carrying the Peptidyl-Prolyl cis/trans Isomerase Activity FEBS Lett. 384, 117-122 (1996)
C. Scholz, T. Zarnt, G. Kern, K. Lang, H. Burtscher, G. Fischer & F. X. Schmid FKBP12: Autocatalytic Folding of a Folding Catalyst J. Biol. Chem. 271, 12703-12707 (1996)
S. Meyer, M. Drewello & G. Fischer Influence of Helix Formation on cis/trans Isomerism of Xaa-Pro Bonds Flanking the Helical Segment Biol. Chem. 377, 489-495 (1996)
B. Schmidt, T. Tradler, J.-U. Rahfeld, B. Ludwig, B. Jain, K. Mann, K. P. Rücknagel, B. Janowski, A.Schierhorn, G. Küllertz, J. Hacker & G. Fischer A Cyclophilin-like Peptidyl-Prolyl cis/trans Isomerase from Legionella pneumophila - Characterisation, Molecular Cloning and Overexpression Mol. Microbiol. 21, 1147-1160 (1996)
M. Schutkowski, M. Drewello, S. Wöllner, M. Jakob, U. Reimer, G. Scherer, A. Schierhorn & G. Fischer Extended Binding Sites of Cyclophilin as Revealed by the Interaction with HIV-1 Gag Polyprotein Derived Oligopeptides FEBS Lett. 394, 289-294 (1996)
C. Scholz, G. Stoller, T. Zarnt, G. Fischer & F. X. Schmid Cooperation of Enzymatic and Chaperone Functions of Trigger Factor in the Catalysis of Protein Folding EMBO J. 16, 54-58 (1997)
M. Kramer & G. Fischer FKBP-like Catalysis of Peptidyl-Prolyl cis/trans Isomerization by Micelles and Membranes Biopolymers 42, 49-60 (1997)
Y. Zhao, Y. Chen, M. Schutkowski, G. Fischer & H. Ke Cyclophilin A Complexed with a Fragment of HIV-1 gag-Protein: Insights into HIV-1 Infectious Activity Structure 5, 139-146 (1997)
90. U. Reimer, M. Drewllo, M. Jakob, G. Fischer & M. Schutkowski Conformational State of a 25-mer Peptide from the Cyclophilin-binding Loop of the Human Immunodeficiency Virus Typ 1 Capsid Protein Biochem. J. 326, 181-185(1997)
B. Janowski & G. Fischer Modulation of Cyclosporin A/Cyclophilin Interactions by Drug Vehicles Bioorg. Medicinal Chem. 5, 179-186 (1997)
S. Hottenrott, T. Schumann, A. Plückthun, G. Fischer & J.-U. Rahfeld The Escherichia coli SlyD is a Metal Ion Regulated Peptidyl-Prolyl cis/trans Isomerase J. Biol.Chem. 272, 15697-15701 (1997)
T. Tradler, G. Stoller, K. P. Rücknagel, A. Schierhorn, J.-U. Rahfeld & G. Fischer Comparative Mutational Analysis of Peptidyl Prolyl cis/trans Isomerases: Active Sites of Escherichia coli Trigger Factor and Human FKBP12 FEBS Lett. 407, 184-190 (1997)
T. Zarnt, T. Tradler, G. Stoller, C. Scholz, F. X. Schmid & G. Fischer Modular Structure of the Trigger Factor Required for High Activity in Protein Folding J. Mol. Biol. 271, 827-837(1997)
M. Schutkowski, M. Jakob, G. Landgraf, I. Born, K. Neubert & G. Fischer Probing Substrate Backbone Function in Prolyl Oligopeptidase Catalysis: Large Positional Effects of Peptide Bond Monothioxylation Eur. J. Biochem. 245, 381-385 (1997)
T. Pfeifer, A. Schierhorn, R. Friedemann, M. Jakob, R. Frank, M. Schutkowski & G. Fischer Specific Fragmentation of Thioxo Peptides Facilitates the Assignment of the Thioxylated Amino Acids Mass Spectrom. 32, 1064-1071 (1997)
S. Heinze, M. Ritzau, W. Ihn, H. Hulsmann, B. Schlegel, K. Dornberger, W. F. Fleck, M. Zerlin, C. Christner, U. Gräfe, G. Küllertz, & G. Fischer Lipohexin, a New Inhibitor of Prolyl Endopeptidase from Moeszia Lintneri (HKI-0054) and Paecilomyces Sp. (HKI-0055HKI-0096)1. Screening, Isolation and Structure Elucidation Antibiotics 50, 379-383 (1997)
C. Christner, M. Zerlin, U. Gräfe, S. Heinze, G. Küllertz & G. Fischer Lipohexin, a New Inhibitor of Prolyl Endopeptidase from Moeszia Lintneri (HKI-0054) and Paecilomyces Sp. (HKI-0055 HKI-0096).2. Inhibitory Activities and Specificity J. Antibiotics 50, 384-389 (1997)
B. Janowski, S. Wöllner, M. Schutkowski & G. Fischer A Protease-free Assay for Peptidyl Prolyl cis/trans Isomerases Using Standard Peptide Substrates Anal. Biochem. 252, 299-307 (1997)
100. C. Scholz, J. Rahfeld, G. Fischer & F. X. Schmid Catalysis of Protein Folding by Parvulin J. Mol. Biol. 273, 752-762 (1997)
U. Reimer, N. El Mokdad, M. Schutkowski & G. Fischer Intramolecular Assistance of cis/trans Isomerization of the His-Pro Moiety Biochemistry 36, 13802-13808 (1997)
M. B. Yaffe, M. Schutkowski, M. Shen, X. Z. Zhou, T. Sukenberg, J.-U. Rahfeld, J. Xu, J. Kuang, M. W. Kirschner, G. Fischer, L. C. Cantley & K. Ping Lu Sequence-specific and Phosphorylation-dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism Science 278, 1957-1960 (1997)
F. Thunecke & G. Fischer Separation of cis/trans Conformers of Human and Salmon Calcitonin by Low Temperature Capillary Electrophoresis Electrophoresis 19, 288-295 (1998)
M. Brandsch, F. Thunecke, G. Küllertz, M. Schutkowski, G. Fischer & K. Neubert Evidence for the Absolute Conformational Specificity of the Intestinal H+/Peptide Symporter (PEPT1) J. Biol. Chem. 273, 3861-3864 (1998)
M. Schutkowski, A. Bernhardt, X. Z. Zhou, M. Shen, U. Reimer, J.-U. Rahfeld, K. Ping Lu & G. Fischer Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition Biochemistry 37, 5566-5675 (1998)
M. Lopez-Ilasaca, C. Schiene, G. Küllertz, T. Tradler, G. Fischer & R. Wetzker Effects of FKBP12 and FK506 on Autophosphorylation of Epidermal Growth Factor Receptor J. Biol. Chem. 273, 9430-9434 (1998)
M. Keller, C. Sager, P. Dumy, M. Schutkowski, G. Fischer & M. Mutter Enhancing the Proline Effect: Pseudo-Prolines for Tayloring cis/trans Isomerization J. Am. Chem. Soc. 120, 2714-2720 (1998)
L. Henning, C. Christner, M. Kipping, B. Schelbert, P. Rücknagel, G. Küllertz & G. Fischer Selective Inactivation of Parvulin-like Peptidyl-Prolyl cis/trans Isomerization by Juglone Biochemistry (1998)
G. Küllertz, S. Lüthe & G. Fischer Semiautomated Microtiter Plate Assay for Monitoring Peptidylprolyl cis/trans Isomerase Activity in Normal and Pathological Human Sera Clinical Chemistry 44, 502-508 (1998)
110. U. Reimer, G. Scherer, M. Drewello, S. Kruber, M. Schutkowski & G. Fischer Side Chain Effects on Peptidylprolyl cis/trans Isomerization J. Mol. Biol. 279, 449-460 (1998)
C. Scholz, G. Scherer, L. M. Mayr, T. Schindler, G. Fischer & F. X. Schmid Prolyl Isomerases Do Not Catalyze Izomerization of Non-Prolyl Peptide Bonds Biol. Chem. 379, 361-365 (1998)
G. Scherer, M. L. Kramer, M. Schutkowski, U. Reimer & G. Fischer Barriers to Rotation of Secondary Amide Peptide Bonds J. Amer. Chem. Soc. 120, 5568-5574 (1998)
G. Fischer, T. Tradler & T. Zarnt The Mode of Action of Peptidyl Prolyl cis/trans Isomerases in vivo: Binding vs. Catalysis FEBS Lett. 426, 17-20 (1998)
C. Christner, G. Küllertz, G. Fischer, M. Zerlin, S. Grabley, R. Thiericke, A. Taddei & Z. Zeeck Albocycline-and Carbomycin-type Macrolides, Inhibitor of Human Prolyl Endopeptidases J. Antibiot. 51, 368-371 (1998)
C. Schiene, U. Reimer, M. Schutkowski & G. Fischer Mapping the Stereospecificity of Peptidyl Prolyl cis/trans Isomerases FEBS Lett. 432, 202-206 (1998)
O. Kops, C. Eckerskorn, S. Hottenrott, G. Fischer, H. F. Mi & M. Tropschug Ssp1, a Site-specific Parvulin Homolog from N.crassa Active in Protein Folding J. Biol. Chem. 273, 31971-31976 (1998)
J. Hani, B. Schelbert, A. Bernhardt, H. Domdey, G. Fischer, K. Wiesbauer & J.-U. Rahfeld Mutations in a Peptidylprolyl-cis/trans Isomerase Gene Lead to a Defect in 3´-End Formation of a Pre-mRNA in S. cerevisiae J. Biol. Chem. 274, 108-116 (1999)
S. A. Teter, W. A. Houry, D. Ang, T. Tradler, D. Rockabrand, G. Fischer, P. Blum, C. Georgopoulos & F. U. Hartl Polypeptide Flux through Bacterial Hsp70: DnaK Cooperates with Trigger Factor in Chaperoning Nascent Chains Cell 97, 755-765 (1999)
T. Uchida, F. Fujimori, T. Tradler, G. Fischer & J.-U. Rahfeld Identification and Characterization of a 14 kDa Human Protein as a Novel Parvulin-like Peptidyl Prolyl cis/trans Isomerase FEBS Lett. 446, 278-282 (1999)
120. R. Golbik, G. Fischer & A. Fersht Folding of Barstar C40A, C82A, P37A nd Catalysis of Peptidyl Prolyl cis/trans Isomerization by Human Cytosolic Cyclophilin (Cyp18) Protein Sci. 8, 1505-1514 (1999)
G. Küllertz, A. Liebau, P. Rücknagel, A. Schierhorn, B. Dietrich, G. Fischer & M. Luckner Stress-induced Expression of Cyclophilins in Proembryonic Masses of D. lanata does not Protect Against Freezuing/Thawing Stress Planta 208, 599-605 (1999)
C. Christner, R. Wyrwa, S. Marsch, G. Küllertz, R. Thiericke, S. Grabley, D. Schumann & G. Fischer Synthesis and Cytotoxic Evaluation of Cycloheximide Derivatives as Potential Inhibitors of FKBP12 with Neuroregenerative Properties J. Med. Chem. 42, 3615-3622 (1999)
D. Wildemann, M. Drewello, G. Fischer & M. Schutkowski Extremely Selective Mg(ClO4)2 mediated Removal of Bpoc/Ddz Moieties Suitable for the Solid Phase Synthesis of Thioxo Peptides J. Chem. Soc., Chem. Commun, 1809-1810 (1999)
M. Brandsch, I. Knutter, F. Thunecke, B. Hartrodt, I. Born, V. Börner, G. Fischer & K. Neubert Decisive Structural Determinants for the Interaction of Proline Derivates with the Intestinal H+/Peptide Symporter Eur. J. Biochem. 266, 502-508 (1999)
G. Fischer Chemical Aspects of Peptide Bond Isomerization Chem. Soc. Rev 29, 119-127 (2000)
R. Frank, M. Jakob, F. Thunecke, G. Fischer & M. Schutkowski Thioxylation as One-atom Substitution Generates a Photoswitchable Element within the Peptide Backbone Angew. Chem. Int. Ed. 39 1120-1122 (2000)
G. Fischer & C. Schiene Enzymes that Catalyze Restructuring of Proteins Curr. Opin. Struct. Biol. 10, 40-45 (2000)
A. Navarrete Santos, S. Körber, G. Küllertz, G. Fischer & B. Fischer Oxygen Stress Increases Prolyl cis/trans Isomerase Activity and Expression of Cyclophilin 18 in Rabbit Blastocytes Biol. Reprod. 62,1-7 (2000)
T. Herdegen, G. Fischer & B. G. Gold Immunophilin ligands as a Novel Treatment for Neurological Disorders Trends Pharmacol. Sci. 21, 3-5 (2000)
130. K. Piechaczek, U. Dobrindt, A. Schierhorn, G. Fischer, M. Hecker & J. Hacker Influence of Pathogenicity Islands and the Minor leuX-encoded tRNA5Leu on the Proteome Pattern of the Uropathogenic E. coli Strain 536 Int. Med. Microbiol. 290, 75-84 (2000)
E. Sekerina, J. U. Rahfeld, J. Müller, J. Fanghänel, C. Rascher, G. Fischer & P. Bayer NMR Solution Structure of hPar14 Reveals Similarity to the Peptidyl Prolyl cis/trans Isomerase Domain of the Mitotic
Regulator hPin1 but Indicates a Different Functionality of the Protein J. Mol. Biol. 301, 1003-1017 (2000)
M. Weiwad, G. Küllertz, M. Schutkowski & G. Fischer Evidence that the Substrate Backbone Conformation is Critical to Phosphorylation by p42 MAP Kinase FEBS Lett. 478, 39-42 (2000)
X. Z. Zhou, O. Kops, A. Werner, P.-J. Lu, M. Shen, G. Stoller, G. Küllertz, M. Stark, G. Fischer & K. P. Lu Pin1 ependent Prolyl Isomerization Regulates Dephosphorylation of Cdc25C and Tau Protein Mol. Cell 6 873-883 (2000)
G. C. Huang, Z. Y. Li, J. M. Zhou & G. Fischer Assisted folding of D-glyceraldehyde-3-phosphate dehydrogenase by trigger factor Protein Sci. 9, 1254-1261 (2000)
U. Dobrindt, B. Janke K. Piechaczek G. Nagy, W. Ziebuhr, G. Fischer, A. Schierhorn, A. M. Hecker, G. Blum-Oehler & J. Hacker Toxin Genes on Pathogenicity Islands: Impact for Microbial Evolution Source Int. J. Med. Microbiol. 290, 307-311 (2000)
M. Metzner, G. Stoller, K. P. Rücknagel, K. P. Lu, G. Fischer, M. Luckner & G. Küllertz Functional Replacement of the Essential ESS1 in Yeast by the Plant Parvulin DLPar13 J. Biol. Chem. 276, 13524-13529 (2001)
C. Schiene-Fischer & G. Fischer Direct Measurement Indicates Slow cis/trans Isomerization at the Secondary Amide Peptide Bond of Glycylglycine J. Amer. Chem. Soc. 123, 6227-6231 (2001)
G. Pappenberger, H. Aygün, J. W. Engels, U. Reimer, G. Fischer & T. Kiefhaber Nonprolyl cis Peptide Bonds in Unfolded Proteins Cause Complex Folding Kinetics Nat. Struct. Biol. 8, 452-458 (2001)
M. Kipping, T. Zarnt, S. Kießig, U. Reimer, G. Fischer & P. Bayer Increased Backbone Flexibility in Threonine45 Phosphorylated Hirudin Upon pH Change Biochemistry 40, 7957-7963 (2001)
140. C. Christner, T. Herdegen & G. Fischer FKBP Ligands as Novel Therapeutics for Neurological Disorder Mini Rev. Med. Chem. 1, 377-379 (2001)
A. Ribold-Tunicliffe, B. König, S. Jessen, M. S. Weiss, J. Rahfeld, J. Hacker, G. Fischer & R. Hilgenfeld Crystal Structure of Mip, a Prolylisomerase from Legionella pneumophila Nat. Struct. Biol. 8, 779-784 (2001)
A. Klettner, R. Baumgrass, Y. Zhang, G. Fischer, E. Bürger,T. Herdegen & K. Mielke The Neuroprotective Actions of FKBP Ligands: Neuronal Survival is Triggered by de novo RNA synthesis, but is Independent of Inhibition JNK and Calcineurin Mol. Brain Res. 97, 21-31 (2001)
R. Baumgraß, M. Weiwad, F. Erdmann, J. O. Liu, D. Wunderlich, S. Grabley & G. Fischer Reversible Inhibition of Calcineurin by the Polyphenolic Aldehyde Gossypol J. Biol. Chem. 276, 47914-47921 (2001)
U. Reimer & G. Fischer Local Structural Changes Caused by Peptidyl Prolyl cis/trans Isomerization in the Native State of Proteins Biophys. Chem. 96, 203-212 (2002)
C. Schiene-Fischer, J. Habazettl, F. X. Schmid & G. Fischer The hsp70 Chaperone DnaK is a Secondary Amide Peptide Bond cis/trans Isomerase Nat. Struct. Biol. 9, 419-423 (2002) (Cover feature)
C. Schiene-Fischer, J. Habazettl, T. Tradler & G. Fischer Evaluation of Similarities in the cis/trans Isomerase Function of Trigger Factor and DnaK Biol. Chem. 383, 1865-1873 (2002) (Paper of the Year 2002)
T. A. Surmacz, E. Sekerina, J. U. Rahfeld, G. Fischer & P. Bayer The N-terminal Basic Domain of Human Parvulin hPar14 is Responsible for the Entry to the Nucleus and High-affinity DNA Binding J. Mol. Biol. 321, 235-247 (2002)
Y. Zhang, S. Füssel, U. Reimer, M. Schutkowski & G. Fischer Substrate-based Design of Reversible Pin1 Inhibitors Biochemistry 41, 11868-11877 (2002)
L. Cavarec, T. Kamphausen, B. Dubourg, I. Callebaut, F. Lemeunier, D. Metivier, J. Feunteun, G. Fischer & N. Modjtahedi Identification and Characterization of Moca-cyp: a Drosophila melanogaster Nuclear Cyclophilin J. Biol. Chem. 25, 41171-41182 (2002)
150. J. Fanghänel & G. Fischer Thermodynamic Characterization of the Interaction of Human Cyclophilin 18 with Cyclosporin A Biophys. Chem. 100, 351-366 (2003)
J. H. Helbig, H. Knospe, B. Bubert, C. Yu, C. P.Lück, A. Riboldi-Tunicliffe, R. Hilgenfeld, E. Jacobs, J. Hacker, B. König & G. Fischer The PPIase Active Site of Legionella pneumophila Mip Protein
is Involved in the Infection of Eukaryotic Host Cells Biol. Chem. 384, 125-137 (2003)
G. Fischer & T. Aumüller Regulation of Peptide Bond cis/trans Isomerization by Enzyme Catalysis and its Implications in Physiological Processes Rev. Physiol. Biochem. Pharmacol. 148, 105-150 (2003)
G. Blaha , D. N. Wilson, G. Stoller, G. Fischer, R. Willumeit & K. H. Nierhaus Localization of the Trigger Factor Binding Site on the Ribosomal 50S Subunit J. Mol. Biol. 326, 887-897 (2003)
T. Reimer, M. Weiwad, A. Schierhorn, P.-K. Ruecknagel, J.-U. Rahfeld, P. Bayer & G. Fischer Phosphorylation of the N-terminal Domain Regulates Subcellular Localization and DNA-binding Properties of the Peptidyl-Prolyl cis/trans Isomerase hPar14 J. Mol. Biol. 330, 955-965 (2003)
R. Köhler, J. Fanghänel, B. König, E. Luneberg, M. Frosch, J. U. Rahfeld, R. Hilgenfeld, G. Fischer, J. Hacker & M. Steinert Biochemical and functional analyses of the Mip protein: Influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella Infect. Immun. 71, 4389-4397 (2003)
S. Brecht, K. Schwarze, V. Waetzig, C. Christner, S. Heiland, G. Fischer, K. Sartor & T. Herdegen Changes in Peptidyl Prolyl cis/trans Isomerase Activity and Fk506 binding Protein Expression Following Neuroprotection by Fk506 in the Ischemic Rat Brain Neuroscience 120, 1037-1048 (2003)
R. Baumgraß, Y. Zhang, F. Erdmann, A. Thiel, M. Weiwad, A. Radbruch & G. Fischer Substitutions in Position 3 of Cyclosporin A Abolishes the Cyclophilin-mediated Gain-of-function Mechanism but not Immunosuppression J. Biol. Chem. 279, 2470-2479 (2004)
M. Weiwad, A. Werner, P. Rücknagel, A. Schierhorn, G. Küllertz & G. Fischer Catalysis of Proline-directed Protein Phosphorylation by Peptidyl-Prolyl cis/trans Isomerases J. Mol. Biol. 339, 635-646 (2004)
B. Dubourg, T. Kamphausen, M. Weiwad, G. Jahreis, J. Feunteun, G. Fischer & N. Modjtahedi The Human Nuclear SR-Cyp Is a Cell-cycle Regulated Cyclophilin J. Biol. Chem. 279, 23322-22330 (2004)
160. Y. Zhang, R. Baumgraß, M. Schutkowski & G. Fischer Branches on the -C Atom of Cyclosporin A Residue 3 Result in Direct Calcineurin Inhibition and Fast Cyclophilin 18 Binding Chembiochem 5, 1006-1009 (2004)
A. Kühlewein, G. Voll, B. Hernandez Alvarez, H. Kessler, G. Fischer, J.-U. Rahfeld & G. Gemmecker The Solution Structure of Escherichia coli Par10: Prototypic Member of the Parvulin Family of Peptidyl Prolyl cis/transIsomerases Protein Sci. 13, 2378-2387 (2004)
J. Fanghänel & G. Fischer Insights into the Catalytic Mechanism of Peptidyl Prolyl cis/trans Isomerases Frontiers Biosci. 9, 4553-4587 (2004)
A. Manteca, T. Kamphausen, J. Fanghänel, G. Fischer & J. Sanchez Cloning and Characterization of a Streptomyces antibioticus ATCC11891 Cyclophilin Related to Gram Negative Bacteria Cyclophilins FEBS Lett. 572, 19-26 (2004)
S. Watanabe, S. Tsuruoka, S. Vijayakumar, G. Fischer, Y. Zhang, A. Fujimura, Q. Al-Awqati & G. J. Schwartz Cyclosporin A Produces Distal Renal Tubular Acidosis by Blocking Peptidyl Prolyl cis/trans Isomerase Activity of Cyclophilin Amer. J. Physiol. 288, F40-F47 (2005)
Y. Zhang, F. Erdmann, R. Baumgrass, M. Schutkowski & G. Fischer Unexpected Side Chain Effects at Residue 8 of Cyclosporin A Derivatives Allow Photoswitching of Immunosuppression J. Biol. Chem. 280, 4842-4850 (2005)
M. Weiwad, F. Edlich, F. Erdmann, F. Jarczowski, S. Kilka, M. Dorn, A. Pechstein & G. Fischer A Reassessment of the Inhibitory Capacity of FKBP38 on Calcineurin FEBS Lett. 579, 1591-1596 (2005)
C. Yu, M. Malesevic, G. Jahreis, M. Schutkowski, G. Fischer & C. Schiene-Fischer Revealing the Architecture of Protein-Ligand Binding Sites with Template-Assisted Intramolecular Peptide-Peptide Interactions Angew. Chem. Int. Ed. 44, 1408-1412 (2005)
M. Horstmann, T. Kamphausen, K. Schweimer, M. Steinert, J. Hacker, A. Haase, P. Rösch, G. Fischer & C. Faber 1H, 13C, 15N Backbone and Side Chain Resonance Assignment of Mip 77-213 the PPIase Domain of Legionella pneumophila Mip Protein Protein Sci. 31, 77-78 (2005)
F. Edlich, M. Weiwad, F. Erdmann, J. Fanghänel, F. Jarczowski, J.-U. Rahfeld & G. Fischer Bcl-2 Regulator FKBP38 is Activated by Ca2+/Calmodulin EMBO J. 24, 2688-2699 (2005)
170. H. Satzger, C. Root, P. Gilch, W. Zinth, D. Wildemann & G. Fischer Photoswitchable Elements within a Peptide Backbone- Ultrafast Spectroscopy of Thioxylated Amides J. Phys. Chem. B 109, 4770-4775 (2005)
R. Leuzzi, L. Serino, M. Scraselli, S. Savino, M. R. Fontana, E. Monaci, A. Taddei, G. Fischer, R. Rappuoli & M. Pizza Ng-MIP, a Surface Exposed Lipoprotein of Neisseria gonorrhoeae, has a cis/trans Peptidyl Prolyl isomerase (PPIase) Activity and is Involved in Persistence in Macrophages Mol. Microbiol. 58, 669-681 (2005)
F. Eckerdt, J. Yuan, K. Saxena, B. Martin, S. Kappel, C. Lindenau, A. Kramer, S. Naumann, S. Daum, G. Fischer, I. Dikic, M. Kaufmann & K. Strebhardt Polo-like Kinase 1 Mediated Phosphorylation of Pin1 Stabilizes Pin1 by Inhibiting its Ubiquitination in Human Cells J. Biol. Chem. 44, 36575-36583 (2005)
M. Maestre-Martinez, F. Edlich, F. Jarczowski, M. Weiwad, G. Fischer & C. Lücke NMR Structure Note: hFKBP38D, the Fk506 Binding Domain of Human FKBP38 J. Biomol. NMR 34, 197-202 (2006)
D. Wildemann, F. Erdmann, B. Hernandez Alvarez, G. Stoller, X. Z. Zhou, J. Fanghänel, M. Schutkowski, K. P. Lu & G. Fischer Nanomolar Inhibitors of the Peptidyl Prolyl cis/trans Isomerase Pin1 by Screening of a Combinatorial Peptide Library J. Med. Chem. 49, 2147-2150 (2006)
F. Edlich, M. Weiwad, D. Wildemann, F. Jarczowski, S. Kilka, M.-C. Moutty, G. Jahreis, C. Lücke, W. Schmidt, F. Striggow & G. Fischer The Specific FKBP38 inhibitor N-(N’,N’-dimethylcarboxamido-methyl)-cycloheximide has Potent Neurotrophic Properties in an Ischemia Model J. Biol. Chem. 281, 14961-14970 (2006) (Paper of the Week, News article, Cover Feature)
J. Fanghänel, S. Wawra, C. Lücke, D. Wildemann & G. Fischer Isothermal Calorimetry as a New Tool to Investigate Slow Conformational Changes in Proteins and Peptides Anal. Chem. 78, 4517-4523 (2006)
S. Daum, F. Erdmann, G. Fischer, B. Féaux de Lacroix, A. Hessamian-Alinejad, S. Houben, W. Frank & M. Braun Aryl Indanyl Ketones: Efficient Inhibitors of the Human Peptidyl Prolyl cis/trans Isomerase Pin1 Angew. Chem. Int. Ed. 45, 7454-7458 (2006)
S. Wawra & G. Fischer Polypeptide Binding Proteins: What Remains to be Discovered? Mol. Microbiol. 61, 1388-1396 (2006)
M. Weiwad, F. Edlich, S. Kilka, F. Erdmann, F. Jarczowski, M. Dorn, M.-C. Moutty & G. Fischer Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins Biochemistry 45, 15776-15784 (2006)
180. M. Horstmann, P. Ehses, K. Schweimer, M. Steinert, T. Kamphausen, G. Fischer, J. Hacker, P. Rösch & C. Faber Domain Motion of the Mip Protein from Legionella pneumophila Biochemistry 45, 12303-12311 (2006)
F. Erdmann & G. Fischer The Nickel-regulated Peptidyl Prolyl cis/trans Isomerase SlyD Met. Ions Life. Sci. 2 501-528 (2007)
F. Edlich, F. Jarczowski, F. Erdmann, M.-C. Moutty, M. Weiwad & G. Fischer Calmodulin/Ca2+-mediated interaction of FKBP38 of SHP90 regulates apoptosis in neuronal cells J. Biol. Chem. 282, 15341-15348 (2007)
C. Wagner, A. Salam Khan, T. Kamphausen, B. Schmausser, U. Lorenz, G. Fischer, J. Hacker & M. Steinert Collagen binding of Mip enables Legionella pneumophila to transmigrate through the lung epithelial barrier Cell. Microbiol. 9, 450-462 (2007)
D. Wildemann, C. Schiene-Fischer, T. Aumüller, A. Bachmann, T. Kiefhaber, C. Lücke & G. Fischer A Nearly Isosteric Photosensitive Amide-Backbone Substitution Allows Enzyme Activity Switching in Ribonuclease S J. Am. Chem. Soc. 129, 4910-4918 (2007)
D. Wildemann, B. Hernandez Alvarez, G. Stoller, X. Z. Zhou, K. P. Lu, F. Erdmann & G. Fischer Specific Pin1 Inhibitors Reveal an Essential Role of Pin1 in Development of Xenopus laevis Embryos Biol. Chem. 388, 1103-1111 (2007)
M. Sieber, M. Karanik, C. Brandt, C. Blex, M. Podtschaske, F. Erdmann, R. Rost. E. Serfling, J. Liebscher, M. Pätzel, A. Radbruch, G. Fischer & R. Baumgraß Inhibition of Calicneurin-NFAT Signaling by the Pyroazolopyrimidine Compound NCI3 Eur. J. Immunol. 37, 2617-2626 (2007)
Y. Zhang, S. Daum, D. Wildemann, X. Z. Zhou, M. A. Verdecia, M. E. Bowman, C. Lücke, T. Hunter, K. P. Lu, G. Fischer & J. P. Noel Structural Basis for High-Affinity Peptide Inhibition of Human Pin1 ACS Chemical Biology 2, 320-328 (2007)
R. Siegrist, M. Zürcher, C. Baumgartner, P. Seiler, F. Diederich, S. Daum, G. Fischer, C. Klein, M. Dangl, & M. Schwaiger A Novel Synthesis of Highly Substituted Perhydropyrrolizines, Perhydroindolizines and Pyrrolidines; Inhibition of the Peptidyl-Prolyl cis/trans Isomerase (PPIase) Pin1 Helv. Chim. Acta 90, 217-259 (2007)
F. Edlich, M. Maestre Martinez, F. Jarczowski, M. Weiwad, M.-C. Moutty, M. Malešević, G. Jahreis, G. Fischer & C. Lücke A Novel Calmodulin/Ca2+ Target Recognition Activates the Bcl-2 Regulator FKBP38 J. Biol. Chem. 282, 36496-36504 (2007)
190. F. Erdmann, F. Jarczowski, M. Weiwad, G. Fischer & F. Edlich Hsp90-mediated Inhibition of FKBP38 Regulates Apoptosis in Neuroblastoma Cells FEBS Lett. 581, 5709-5714 (2007)
M. Malešević, G. Jahreis, S. Wawra, G. Fischer & C. Lücke Conformational Consequences of Regio and Stereo Selective Disulfide Bridge Oxidation in a Cyclic Peptide Chembiochem 9, 46-49 (2008)
T. Aumüller & G. Fischer Bioactivity of Folding Intermediates Studied by the Recovery of Enzymatic Activity during Refolding J. Mol. Biol. 376, 1478-1492 (2008)
F. Jarczowski, G. Fischer & F. Edlich FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes. Biochemistry 47, 6946-6952( 2008)
A. Reiner, D. Wildemann, G. Fischer & T. Kiefhaber, Effect of Thioxopeptide Bonds on alpha-Helix Structures and Stability. J. Amer. Chem. Soc. 130, 8079-8084 (2008)
K. Peisker, D. Braun, T. Wölfle, J. Hentschel, U. Fünfschilling, G. Fischer, A. Sickmann & S. Rospert
Ribosome-associated Complex Binds to Ribosomes in Close Proximity of Rpl31 at the Exit of the Polypeptide Tunnel in Yeast. Mol. Biol. Cell 19, 5278-5288 (2008)
M. Braun, A. Hessamian-Alinejad, B. F. de Lacroix, B. H. Alvarez & G. Fischer Novel spiroannulated 3-benzofuranones. Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1. Molecules. 13, 995-1003 (2008).
F. Jarczowski, G. Jahreis, F. Erdmann, A. Schierhorn, G. Fischer & F. Edlich FKBP36 is an inherent multi-functional glyceraldehyde-3-phosphate dehydrogenase inhibitor. J. Biol. Chem. 284, 766-773 (2009)
K. Bauer, A. K. Kretzschmar, H. Cvijic, C. Blumert, D. Löffler, K. Brocke-Heidrich, C. Schiene-Fischer, G. Fischer, A. Sinz, C. V. Clevenger & F. Horn Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells. Oncogene, 28, 2784-2795 (2009)
K. Uhlenbrock , M. Weiwad, R. Wetzker, G. Fischer, A. Wittinghofer & I. Rubio Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.FEBS Lett. 583, 965-970 (2009)
200. S. Kilka,F. Erdmann, A. Migdoll, G. Fischer & M. Weiwad The Proline-Rich N-Terminal Sequence of Calcineurin A beta Determines Substrate Binding.Biochemistry 48, 1900-1910 (2009)
N.N. Barak, P. Neumann , M Sevvana, M. Schutkowski, K. Naumann, M. Malesevic, H. Reichardt & G. Fischer, M. T. Stubbs, & D. M. Ferrari Crystal Structure and Functional Analysis of the Protein Disulfide Isomerase-Related Protein ERp29. J. Mol. Biol. 385, 1630-1642 (2009)
Y. Zhang, F. Erdmann & G. Fischer Photoswitching with Protein Borrowing Modulates Affinity. Nat. Chem. Biol .5, 224-226 (2009) Cover Feature
A. Thiele, J. Zerweck, M. Weiwad, G. Fischer & M. Schutkowski High-density Peptide Microarrays for Reliable Identification of Phosphorylation Sites and Upstream Kinases. Methods Mol. Biol. 570, 203-219 (2009)
G. Zoldak, T. Aumüller, C. Lücke, J. Hritz, C. Oostenbrink, G. Fischer & F. X. Schmid A Library of Fluorescent Peptides for Exploring the Substrate Specificities of Prolyl Isomerases. Biochemistry 48, 10423-10436 (2009)
F. Erdmann, M. Weiwad , S. Kilka, M. Karanik, M. Paetzel, R. Baumgrass, J. Liebscher & G. Fischer The novel calcineurin inhibitor CN585 has potent immunosuppressive properties in stimulated human T cells. J. Biol. Chem. 285, 1888-1898 (2010)
M. Malesević, J. Kühling, F. Erdmann, M. A. Balsley, M. I. Bukrinsky, S. L. Constant, & G. Fischer A cyclosporin derivative discriminates between extracellular and intracellular cyclophilins. Angew. Chem. Int Ed Engl , 49, 213-215 (2010)
T. Aumüller, G. Jahreis, G. Fischer & C. Schiene-Fischer The Role of Prolyl cis/trans Isomers in the
Cyclophilin Assisted P. syringae AvrRpt2 Protease Activation. Biochemistry (2010)
S. Hopkins, B. Scorneaux, Z. Huang, M. G. Murray, S. Wring, C. Smitley, R. Harris, F. Erdmann, G. Fischer & Y. Ribeill SCY-635: A Novel Non-immunosuppressive Analog of Cyclosporin A that Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication in vitro. Antimicrob Agents Chemother (2010)
Bücher und Monographien:
G. Küllertz, G. Fischer & A. Barth (Eds.), Dipeptidyl-peptidase IV - Biochemie,Physiologie und Pathobiochemie, Institut für Wirkstofforschung Berlin -Friedrichsfelde, 223 Seiten (1986)
G. Fischer in Struktur-Funktions-Beziehungen in Proteasen und ausgewählten Proteinen, A. Schellenberger & H.-R.Schütte, (Eds.), Verlag der Wissenschaften, Berlin, 25-50 und 153-160 (1985)
G. Fischer in Enzyme Mechanisms, M. Page & A. Williams (Eds.), Royal Society of Chemistry Publ. London, 228-240 (1987)
G. Fischer in TPP Biochemistry Presteady-state-Kinetics in Proteolytic Reactions TPP Biochemistry, 123-128 (1988)
G. Fischer in Enzymkatalyse, (Hsg. A. Schellenberger) Gustav Fischer Verlag Jena,12-71 (1989)
G. Fischer Langsame Konformationsänderungen und enzymatische Katalyse bei der Faltung von Proteinen, Jahrbuch Biotechnologie 4. Ausgabe P. Präve (Ed.), 33-57 (1992)
G. Fischer „Slow Conformational Changes and their Enzymology Nova Acta Leopoldina NF 69, 35-53(1989)
G. Fischer Das Rätsel der Faltung Chemie heute 1991/1992, 29-31
G. Fischer Faltung der Proteine:Der Weg vom Baustein zur Funktion Verh. Ges. dt. Naturf. 117, 245-260 (1992)
G. Fischer Enzymkatalyse bei Konformerenumwandlungen Nachr.Chem.Tech.Lab. 42, 987-995(1994)
G. Fischer Molekülkonformation und biologisches Signal Nova Acta Leopold.NF 72, 221-236 (1995)
G. Fischer Die Dominanz der äußeren Form in der Biochemie, Futura 8, 216-221(1994)
G. Fischer in 45 Jahre Fonds der chemischen Industrie, VCI Frankfurt/Main (Ed.), 23-32 (1995)
G. Fischer Prolyl cis/trans Isomerases-Folding Helper Enzymes, Biol.Chem. Hoppe-Seyler 376, S96 (1995)
G. Fischer Peptidyl-Prolyl cis/trans Isomerasen:Prolinspezifische Bindeproteine oder Faltungskatalysatoren, Biospektrum 2, 43-47 (1996)
G. Fischer & J.-U. Rahfeld in Guidebook to Molecular Chaperaones and Protein Folding Catalysts, M.-J. Gething (Ed.), Oxford University Press, Oxford, 399-402 & 434-435 (1997)
R. Moerschell, O. Kandor, A. L. Goldberg, G. Fischer & J.-U. Rahfeld in Guidebook to Molecular Chaperaones and Protein Folding Catalysts, M.-J. Gething (Ed.), Oxford University Press, Oxford,404-407 (1997)
G. Fischer in Drug Discovery from Nature, S. Grabley & R. Thiericke (Eds.), Springer-Verlag Berlin, Heidelberg, New York, 157-181 (1999)
G. Fischer & F. X. Schmid in Molecular Chaperones and Folding Catalysts, B. Buckau (Ed.), Harwood Academic Publishers, Amsterdam, 461-491 (1999)
G. Fischer in Enzyclopedia of Molecular Biology, T. E. Creighton (Ed.), J. Wiley & Sons, Inc. New York, 470-471, 599-602, 918, 1814-1815, 2099-2100 (1999)
G. Fischer in Immunophilins in the Brain, B. G. Gold, G. Fischer & T. Herdegen (Eds)., Prous Science, Barcelona, 282 pp (2000)
G. Fischer in Handbook of Protein Folding, J. Buchner & T. Kiefhaber, (Eds.), Wiley-VCH Verlag, Weinheim, 377-401 (2005)
F. Edlich & G. Fischer in Molecular Chaperones in Health and Diseases, M. Gaestel (Ed.), Springer-Verlag Berlin, 359-405 (2006)
G. Fischer & S. Wawra in Cis/trans Isomerization in Biochemistry, C. Dugave (Ed.), Wiley-VCH Verlag, Weinheim, 167-225 (2006)
A. Schellenberger & G. Fischer Säure- und Metallionenkatalyse bei der Jodierung von Brenztraubensäuredialkylamiden Z. Chem. 8, 460-461 (1968)
G. Hübner, G. Fischer & A. Schellenberger Über den Einfluß von Carbonylverbindungen auf die Geschwindigkeit der Hefe-PDC Reaktion Z. Chem. 10, 436-437 (1970)
G. Fischer, G. Oehme & A. Schellenberger Beziehungen zwischen Struktur und UV-Spektren von alpha-Ketosäuren und verwandten alpha-Dicarbonylverbindungen Tetrahedron 27, 5683-5695 (1971)
G. Nafe, G. Hübner, G. Fischer, H. Neef & A. Schellenberger Hinweise auf Konformationsänderungen der Proteinkomponente beim Rekombinations- und Regulationsmechanismus der Hefe-PDC Acta Biol. Med. Germ. 29, 581-594 (1972)
G. Fischer & A. Schellenberger Kinetik der Enolisierung einiger Brenztraubensäureamide Tetrahedron 28, 4113-4123 (1972)
G. Fischer, G. Küllertz & A. Schellenberger Mechanismus der Enolisierung einiger Brenztraubensäureamide Tetrahedron 29, 4313-4320 (1973)
H. Lehmann, G. Fischer, G. Hübner, K.-D. Kohnert & A. Schellenberger The Influence of Steric and Electronic Parameters on the Substrate Behaviour of alpha-Oxo Acids to Yeast Pyruvate Decarboxylase Eur. J. Biochem. 32, 83-87 (1973)
G. Fischer & A. Schellenberger Self-association and Intramolecular Hydrogen Bonding of Monosubstituted Pyruvamides Tetrahedron Lett. 1974, 3307-3310 (1974)
10. G. Hübner, H. Neef, G. Fischer & A. Schellenberger Kinetischer N-15 Isotopieeffekt als direkter Beweis für die Beteiligung der Aminogruppe von Thiaminpyrophosphat an der enzymatischen Decarboxylierung von alpha-Ketosäuren Z. Chem. 15, 221 (1975)
G. Küllertz, G. Fischer & A. Barth Sekundäre D-Isotopieeffekte bei der Hydrolyse von 4-Nitroacetanilid Tetrahedron 32, 759-761 (1976)
G. Fischer, G. Küllertz & A. Schellenberger Sekundäre thermodynamische und kinetische Deuterium- Isotopieeffekte bei nucleophilen Additionsreaktionen an die Carbonylgruppe von Pyruvamid Tetrahedron 32, 1503-1505 (1976)
D. R. Petzold & G. Fischer H-1 nmr spektroskopische Untersuchungen des Systems Thiamin/ Mg2+/Pyruvat in Wasser Studia biophysica 54, 53-56 (1976)
G. Fischer, G. Küllertz, A. Barth & R. Rashid Mechanismus der basischen Hydrolyse von alpha- Aminosäureaniliden Z. Chem. 17, 380-381 (1977)
G. Küllertz, G. Fischer & A. Barth Beiträge zum Katalysemechanismus der Dipeptidyl-peptidase IV Acta Biol. Med. Germ. 37, 559-567 (1978)
G. Fischer, G. Küllertz & A. Barth Mechanismus der basischen Hydrolyse von Oligopeptid-4-nitroaniliden Tetrahedron 34, 2123-2129 (1978)
B. Wolf, G. Fischer und A. Barth Kinetische Untersuchungen an der Dipeptidyl-peptidase IV Acta Biol. Med. Germ. 37, 409-420 (1978)
A. Barth, H. Mager, G. Fischer, K. Neubert & G. Schwarz Struktur-Aktivitäts-Beziehungen bei der enzymatischen Hydrolyse von Dipeptid-arylamiden durch die DP IV Acta Bio. Med. Germ. 39, 1129-1142 (1980)
G. Fischer, G. Schönberner & G. Küllertz Untersuchungen zur Bestimmung der Lipaseaktivität mit titrimetrischen und turbidometrischen Methoden Zbl. Pharm. 120, 1233-1240 (1981)
20. G. Küllertz, G. Fischer & H. Schönberner Einfache titrimetrische Bestimmung der Serumlipase mit der pH-Stat Technik Z. Med. Labor Diagn. 22, 123-128 (1981)
B. Hartrodt, K. Neubert, G. Fischer, U. Demuth, T. Yoshimoto & A. Barth Degradation of ß-Casomorphin-5 by Proline-specific Endopeptidase and Post-proline Cleaving Enzyme Pharmazie 37, 72-73 (1982)
B. Hartrodt, K. Neubert, G. Fischer, H. Schulz & A. Barth Synthese und enzymatischer Abbau von ß-Casomorphin-5 Pharmazie 37, 165-169 (1982)
D. R. Petzold, G. Hübner, G. Fischer, H. Neef & A. Schellenberger H-1 nmr spektroskopische Untersuchungen zur Reaktivität des 2-H Atoms von TPP und Derivaten sowie von deren Komplexen Studia biophysica 87, 15-21 (1982)
G. Fischer, M. Sieber & A. Schellenberger The Carbonyl Reactivity of 3-Bromopyruvate and Related Compounds Bioorg. Chem. 11, 478-484 (1982)
G. Fischer, J. Heins & A. Barth The Conformation Around the Peptide Bond Between the P1 and P2 -Position is Important for the Catalytic Activity of Some Proline-specific Proteases Biochim. Biophys. Acta 742, 452-462 (1983)
G. Fischer, H.-U. Demuth & A. Barth Diacylhydroxylamines as Enzyme-activated Inhibitors for Serine Proteases Pharmazie 38, 249-250 (1983)
W. Kallenbach, G. Küllertz & G. Fischer Untersuchungen zur Bestimmung von Dipeptidyl Peptidase-Aktivitäten im Liquor Cerebrospinalis Psych. Neurol. Med. Psychol. (Leipzig) 36, 295-302 (1984)
W. Geserick, G. Küllertz, W. Keil, G. Fischer & M. Nagy Untersuchungen zum spurenkundlichen Nachweis von Sperma mittels DP IV Kriminalistik und forens. Wiss. 56, 66-69 (1984)
G. Fischer, C. Mech & H. Bang Nachweis einer Enzymkatalyse für die cis/trans Isomerisierung der Peptidbindung in prolinhaltigen Peptiden Biomed. Biochim. Acta 43, 1101-1111 (1984)
30. G. Fischer, H. Bang, E. Berger und A. Schellenberger Conformational Specificity of Chymotrypsin Toward Proline Containing Substrates Biochim. Biophys. Acta 791, 87-97 (1984)
R. L. Stein, H. Fujihara, D. M. Quinn, G. Fischer, G. Küllertz, A. Barth & R. L. Schowen Transition State Structural Features for Anilide Hydrolysis from ß-Deuterium Isotope Effects J. Am. Chem. Soc. 106, 1457-1461 (1984)
G. Fischer und H. Bang The Refolding of Urea-denatured Ribonuclease A is Catalyzed by Peptidyl Prolyl cis/trans Isomerase Biochim. Biophys. Acta 828, 39-42 (1985)
E. Berger, K. Neubert, G. Fischer & A. Barth Synthese des N-terminalen Hexapeptides Met-Ala-Ser-Pro-Phe-Ala, einer Signalsequenz des Leukocyten-Interferons Z. Chem. 25, 179-180 (1985)
G. Küllertz, A. Barth & G. Fischer Die Bestimmung der DP IV in biologischen Materialien J. Clin. Chem. Clin. Biochem. 24, 551-558 (1986)
G. Küllertz, M. Nagy, G. Fischer und A. Barth Isolierung und Characterisierung der DP IV aus humanen Seminalplasma Biomed. Biochim. Acta 45, 291-303 (1986)
W. Kallenbach, G. Küllertz, G. Fischer & A. Barth Die Validität der postprolin-spaltenden Aktivitäten im Liquor cerebrospinalis für die neurologisch-psychatrische Diagnostik Psychiat. Neurol. Med. Psychol. (Leipzig) 38, 456-463 (1986)
W. Kallenbach, G. Küllertz & G. Fischer DP IV -Aktivitäten in Hirnarealen und Nervengewebe des Menschen Pharmazie 41, 819 (1986)
K. Lang, F. X. Schmid & G. Fischer Catalysis of Protein Folding by Prolyl Isomerases Nature 329, 268-270 (1987)
E. Berger, G. Fischer, K. Neubert & A. Barth Stepwise Degradation of the Hexapeptide Met-Ala-Ser-Pro-Phe-Ala by Dipeptidyl Peptidase IV Biomed. Biochim. Acta 46, 671-676 (1987)
40. S. Flatau, G. Fischer, E. Kleinpeter & A. Schellenberger P-31 Investigations on Free and Enzyme-bound Thiamine-pyrophosphate FEBS Lett. 233, 379-382 (1988)
G. Fischer, S. Flatau, A. Schellenberger & A. Zschunke C-13 NMR Investigations of the Structure of alpha-Keto Acids in Aqueous Solutions J. Org. Chem. 53, 214-216 (1988)
H. U. Demuth, R. Baumgrass, C. Schaper, G. Fischer & A. Barth DP IV-Inactivation with N-Peptidyl-O-Aroyl Hydroxylamines J. Enzyme Inhibition 2, 129-142 (1988)
G. Fischer Trends in Protease Inhibition Natural Prod. Reports 465-495 (1988)
G. Fischer, B. Wittmann-Liebold, K. Lang, T. Kiefhaber & F. X. Schmid Cyclophilin and Peptidyl-Prolyl cis/trans Isomerase are Probably Identical Proteins Nature 337, 476-478 (1989)
G. Küllertz, W. Kallenbach, Gabriele Küllertz & G. Fischer Post-Prolin Hydrolyseaktivitäten im Liquor Cerebrospinalis Z. Med. Lab. Diagn. 30, 273-280 (1989)
G. Fischer, E. Berger & H. Bang Kinetic ß-Deuterium Isotopic Effects Suggest a Covalent Mechanism for the Protein Folding Enzyme Peptidyl-Prolyl cis/trans Isomerase FEBS Lett. 250, 267-270 (1989)
H.-U. Demuth, G. Fischer, A. Barth & R. L. Schowen N-O bond Fission as the Rate Determining Step in the Aqueous Conversion of N-Peptidyl-O-4-Nitrobenzoyl Hydroxylamines to p-Nitrobenzoic Acid and Peptidyl Hydroxamic Acid J. Org. Chem. 54, 5880-5883 (1989)
G. Küllertz, W. Kallenbach, G. Küllertz & G. Fischer Post-Prolin Hydrolyseaktivitäten im Liquor Cerebrospinalis Z. med. Lab. Diagn. 30, 273-280 (1989)
G. Fischer & F. X. Schmid The Mechanism of Protein Folding. Implications of In-Vitro Refolding Models for the de-novo Protein Folding and Translocation in the Cell Biochemistry 29, 2205-2212 (1990)
50. E. R. Schönbrunner, S. Mayer, M. Tropschug, G. Fischer, N. Takahashi & F. X. Schmid Catalyis of Protein Folding by Cyclophilins from Different Species is Highly Conserved J. Biol. Chem. 266, 3630-3635 (1990)
F. Janowski, G. Fischer, W. Urbaniak, Z. Foltynowicz & B. Marciniec Aminopropylsilane Treatment of the Surface of Porous Glasses Suitable for Enzyme Immobilisation J. Chem. Tech. Biotechnol. 51, 263-273 (1991)
D. Hübner, B. Hartrodt, E. Kleinpeter, D. Ströhl, W. Brandt, H. Schinke, M. Wahab, & G. Fischer Conformational Analysis of the Tetrapeptide Pro-D-Phe-Pro-Gly in Aqueous Solution Biochem. Biophys. Res. Commun. 177, 271-278 (1991)
D. Hübner, T. Drakenberg, S. Forsen & G. Fischer PPIase Activity as Studied by Dynamic Proton NMR FEBS Lett. 284, 79-81 (1991)
H. Bang & G. Fischer Slow Conformational Changes in Protein Folding can be Accelerated by Enzymes Biomed. Biochim. Acta 50, S137-S142 (1991)
G. Fischer, H. Bang, B. Ludwig, K. Mann & J. Hacker Mip Protein of Legionella pneumophila Exhibits Peptidyl Prolyl cis/trans Isomerase Activity Mol. Microbiol. 6, 1375-1383 (1992)
G. Willimsky, H. Bang, G. Fischer & M. A. Marahiel Characterization of cspB, a Bacillus subtilis Inducible Cold Shock Gene Affecting Cell Viability at Low Temperatures J. Bacteriol. 174, 6326-6335 (1992)
M. Herrler, H. Bang, K. Brune, G. Fischer & M. A. Marahiel Peptidyl Prolyl cis/trans Isomerase from Bacillus subtilis: A Prokaryotic Enzyme that is Highly Sensitive to Cyclosporin A FEBS Lett. 309, 231-234 (1992)
B. Hartrodt, H. Schinke, D. Hübner, G. Fischer & K. Neubert Synthesis, Conformation and Pharmacology of des-Tyr1 -ß-Casomorphin-5 Analogues Peptides 661-662 (1992)
D. Kern, T. Drakenberg, M. Witström, S. Forsen, H. Bang & G. Fischer The cis/trans Interconversion of the Calcium Regulating Hormone Calcitonin is Catalyzed by Cyclophilin FEBS Lett. 323, 198-202 (1993)
60. J. Hacker, M. Ott, E. Wintermeyer, B. Ludwig & G. Fischer Analysis of Virulence Factors of L. pneumophila Zbl. Bakter. 278, 348-358 (1993)
J. Hacker & G. Fischer Immunophilins-Structure,Function Relationship Mol. Microbiol. 10, 445-456 (1993)
G. Fischer About PPIases and their Inhibitors Angew.Chem. 106, 1479-1501 (1994); Angew. Chem. Int. Ed. Engl. 33, 1415-1436 (1994)
M. Schutkowski, K. Neubert & G. Fischer Influence on Proline-specific Enzymes of a Substrate- Containing the Thionoprolyl Peptide Bond Eur. J. Biochem. 221, 455-461 (1994)
B. Ludwig, J. Rahfeld, B. Schmidt, K. Mann, E. Wintermeyer, G. Fischer & J. Hacker Characterization of Mip Proteins of Legionella pneumophila FEMS Microbiol. Lett. 118, 23-30(1994)
S. Meyer, A. Jabs, M. Schutkowski & G. Fischer Separation of cis/trans Isomers of a Prolyl Peptide Bond by Capillary Zone Electrophoresis Electrophoresis 15, 1151-1157 (1994)
G. Küllertz & G. Fischer Influence of Additives on Resolution and Focusing Efficiency in Free Flow Isoelectric Focusing J. Chromatography A 684, 329-341 (1994)
G. Küllertz, S. Meyer & G. Fischer Differentation by Preparative Free Flow IEF of Cyclosporin A Inhibitable Peptidyl-Prolyl cis/trans Isomerases of Human Erythrocytes Electrophoresis 15, 960-967 (1994)
J. Rahfeld, A. Schierhorn, K. Mann & G. Fischer A Novel Peptidyl-Prolyl cis/trans Isomerase from Escherichia coli FEBS Lett. 343, 65-69 (1994)
J. Hacker, M. Ott, B. Ludwig, E. Wintermeyer, J. Rahfeld, G. Fischer, B. Jain & M. Tully Molecular Studies on Toxin Production and Other Virulence Features of Legionella pneumophila Zbl. Bakt. Suppl. 24, 33-42 (1994)
70. G. Kern. D. Kern, F. X. Schmid & G. Fischer Reassessment of the Putative Chaperon Function of Prolyl cis/trans Isomerases FEBS Lett. 348, 145-148(1994)
B. Schmidt, J. Rahfeld, A. Schierhorn, B. Ludwig, J. Hacker & G. Fischer A Homodimer Represents an Acive Species of the Peptidyl-Prolyl cis/trans Isomerase FKBP25mem from Legionella pneumophila FEBS Lett. 352, 185-190 (1994)
J.-U. Rahfeld, K. P. Rücknagel, B. Schelbert, B. Ludwig, J. Hacker, K. Mann & G. Fischer Confirmation of the Existence of a Third Family Among Peptidyl-Prolyl cis/trans Isomerases: Amino Acid Sequence and Recombinant Production of Parvulin FEBS Lett.352, 180-184 (1994)
T. Zarnt, K. Lang, H. Burtscher & G. Fischer Time-dependent Inhibition of Peptidyl-Prolyl cis/trans Isomerases by FK506 is Probably due to cis/trans Isomerization of the Inhibitors Imide Bond Biochem. J. 305, 159-164 (1995)
G. Kern, D. Kern, F. X. Schmid & G. Fischer A Kinetic Analysis of the Folding of Human Carbonic Anhydrase II and its Catalysis by Cyclophilin J. Biol. Chem. 270, 740-745 (1995)
B. Schmidt, G. Fischer, S. König, D. Svergun, V. Volkov & M. H. J. Koch Small-angle X-ray Solution Scattering Study on the Dimerization of the FKBP25mem from Legionella pneumophila FEBS Lett. 372, 169-172 (1995)
G. Stoller, K. P Rücknagel, K. H. Nierhaus, F. X. Schmid, G. Fischer & J.-U. Rahfeld A Ribosome-associated Peptidyl-Prolyl cis/trans Isomerase Identified as the Trigger Factor EMBO J. 14, 4939-4948 (1995)
D. Kern, G. Kern, G. Scherer, G. Fischer & T. Drakenberg A Kinetic Analysis of Cyclophilin-catalyzed Prolyl cis/trans Isomerization by Dynamic NMR Spectroscopy Biochemistry 34, 13594-13602 (1995)
M. Schutkowski, S. Wöllner & G. Fischer Inhibition of Peptidyl-Prolyl cis/trans Isomerase Activity by Substrate-analog Structures: Thioxo tetrapeptide-4-nitroanilides Biochemistry 34, 13016-1326 (1995)
E. Wintermeyer, B. Ludwig, M. Steinert, B. Schmidt, G. Fischer & J. Hacker Influence of Site-specifically Altered Mip Proteins on Intracellular Survival of Legionella pneumophila in Eukariotic Cells Infect. Immun. 63, 4576-4583 (1995)
80. W. Steffan, M. Schutkowski & G. Fischer Synthesis of Chromogenic Proline-containing Glycopeptides J. Chem. Soc., Chem. Commun. 313-314 (1996)
J.-U. Rahfeld, K. P. Rücknagel, G. Stoller, S. M. Horne, A. Schierhorn, K. D. Young & G. Fischer Isolation and Amino Acid Sequence of a New 22kDa FKBP-like Peptidyl-Prolyl cis/trans Isomerase of E. coli: Similarity to Mip-like Proteins of Pathogenic Bacteria J. Biol. Chem. 36, 22130-22138 (1996)
G. Stoller, T. Tradler, K. P. Rücknagel, J.-U. Rahfeld & G. Fischer An 11.8 kDa Proteolytic Fragment of the E. coli Trigger Factor Represents the Domain Carrying the Peptidyl-Prolyl cis/trans Isomerase Activity FEBS Lett. 384, 117-122 (1996)
C. Scholz, T. Zarnt, G. Kern, K. Lang, H. Burtscher, G. Fischer & F. X. Schmid FKBP12: Autocatalytic Folding of a Folding Catalyst J. Biol. Chem. 271, 12703-12707 (1996)
S. Meyer, M. Drewello & G. Fischer Influence of Helix Formation on cis/trans Isomerism of Xaa-Pro Bonds Flanking the Helical Segment Biol. Chem. 377, 489-495 (1996)
B. Schmidt, T. Tradler, J.-U. Rahfeld, B. Ludwig, B. Jain, K. Mann, K. P. Rücknagel, B. Janowski, A.Schierhorn, G. Küllertz, J. Hacker & G. Fischer A Cyclophilin-like Peptidyl-Prolyl cis/trans Isomerase from Legionella pneumophila - Characterisation, Molecular Cloning and Overexpression Mol. Microbiol. 21, 1147-1160 (1996)
M. Schutkowski, M. Drewello, S. Wöllner, M. Jakob, U. Reimer, G. Scherer, A. Schierhorn & G. Fischer Extended Binding Sites of Cyclophilin as Revealed by the Interaction with HIV-1 Gag Polyprotein Derived Oligopeptides FEBS Lett. 394, 289-294 (1996)
C. Scholz, G. Stoller, T. Zarnt, G. Fischer & F. X. Schmid Cooperation of Enzymatic and Chaperone Functions of Trigger Factor in the Catalysis of Protein Folding EMBO J. 16, 54-58 (1997)
M. Kramer & G. Fischer FKBP-like Catalysis of Peptidyl-Prolyl cis/trans Isomerization by Micelles and Membranes Biopolymers 42, 49-60 (1997)
Y. Zhao, Y. Chen, M. Schutkowski, G. Fischer & H. Ke Cyclophilin A Complexed with a Fragment of HIV-1 gag-Protein: Insights into HIV-1 Infectious Activity Structure 5, 139-146 (1997)
90. U. Reimer, M. Drewllo, M. Jakob, G. Fischer & M. Schutkowski Conformational State of a 25-mer Peptide from the Cyclophilin-binding Loop of the Human Immunodeficiency Virus Typ 1 Capsid Protein Biochem. J. 326, 181-185(1997)
B. Janowski & G. Fischer Modulation of Cyclosporin A/Cyclophilin Interactions by Drug Vehicles Bioorg. Medicinal Chem. 5, 179-186 (1997)
S. Hottenrott, T. Schumann, A. Plückthun, G. Fischer & J.-U. Rahfeld The Escherichia coli SlyD is a Metal Ion Regulated Peptidyl-Prolyl cis/trans Isomerase J. Biol.Chem. 272, 15697-15701 (1997)
T. Tradler, G. Stoller, K. P. Rücknagel, A. Schierhorn, J.-U. Rahfeld & G. Fischer Comparative Mutational Analysis of Peptidyl Prolyl cis/trans Isomerases: Active Sites of Escherichia coli Trigger Factor and Human FKBP12 FEBS Lett. 407, 184-190 (1997)
T. Zarnt, T. Tradler, G. Stoller, C. Scholz, F. X. Schmid & G. Fischer Modular Structure of the Trigger Factor Required for High Activity in Protein Folding J. Mol. Biol. 271, 827-837(1997)
M. Schutkowski, M. Jakob, G. Landgraf, I. Born, K. Neubert & G. Fischer Probing Substrate Backbone Function in Prolyl Oligopeptidase Catalysis: Large Positional Effects of Peptide Bond Monothioxylation Eur. J. Biochem. 245, 381-385 (1997)
T. Pfeifer, A. Schierhorn, R. Friedemann, M. Jakob, R. Frank, M. Schutkowski & G. Fischer Specific Fragmentation of Thioxo Peptides Facilitates the Assignment of the Thioxylated Amino Acids Mass Spectrom. 32, 1064-1071 (1997)
S. Heinze, M. Ritzau, W. Ihn, H. Hulsmann, B. Schlegel, K. Dornberger, W. F. Fleck, M. Zerlin, C. Christner, U. Gräfe, G. Küllertz, & G. Fischer Lipohexin, a New Inhibitor of Prolyl Endopeptidase from Moeszia Lintneri (HKI-0054) and Paecilomyces Sp. (HKI-0055HKI-0096)1. Screening, Isolation and Structure Elucidation Antibiotics 50, 379-383 (1997)
C. Christner, M. Zerlin, U. Gräfe, S. Heinze, G. Küllertz & G. Fischer Lipohexin, a New Inhibitor of Prolyl Endopeptidase from Moeszia Lintneri (HKI-0054) and Paecilomyces Sp. (HKI-0055 HKI-0096).2. Inhibitory Activities and Specificity J. Antibiotics 50, 384-389 (1997)
B. Janowski, S. Wöllner, M. Schutkowski & G. Fischer A Protease-free Assay for Peptidyl Prolyl cis/trans Isomerases Using Standard Peptide Substrates Anal. Biochem. 252, 299-307 (1997)
100. C. Scholz, J. Rahfeld, G. Fischer & F. X. Schmid Catalysis of Protein Folding by Parvulin J. Mol. Biol. 273, 752-762 (1997)
U. Reimer, N. El Mokdad, M. Schutkowski & G. Fischer Intramolecular Assistance of cis/trans Isomerization of the His-Pro Moiety Biochemistry 36, 13802-13808 (1997)
M. B. Yaffe, M. Schutkowski, M. Shen, X. Z. Zhou, T. Sukenberg, J.-U. Rahfeld, J. Xu, J. Kuang, M. W. Kirschner, G. Fischer, L. C. Cantley & K. Ping Lu Sequence-specific and Phosphorylation-dependent Proline Isomerization: A Potential Mitotic Regulatory Mechanism Science 278, 1957-1960 (1997)
F. Thunecke & G. Fischer Separation of cis/trans Conformers of Human and Salmon Calcitonin by Low Temperature Capillary Electrophoresis Electrophoresis 19, 288-295 (1998)
M. Brandsch, F. Thunecke, G. Küllertz, M. Schutkowski, G. Fischer & K. Neubert Evidence for the Absolute Conformational Specificity of the Intestinal H+/Peptide Symporter (PEPT1) J. Biol. Chem. 273, 3861-3864 (1998)
M. Schutkowski, A. Bernhardt, X. Z. Zhou, M. Shen, U. Reimer, J.-U. Rahfeld, K. Ping Lu & G. Fischer Role of Phosphorylation in Determining the Backbone Dynamics of the Serine/Threonine-Proline Motif and Pin1 Substrate Recognition Biochemistry 37, 5566-5675 (1998)
M. Lopez-Ilasaca, C. Schiene, G. Küllertz, T. Tradler, G. Fischer & R. Wetzker Effects of FKBP12 and FK506 on Autophosphorylation of Epidermal Growth Factor Receptor J. Biol. Chem. 273, 9430-9434 (1998)
M. Keller, C. Sager, P. Dumy, M. Schutkowski, G. Fischer & M. Mutter Enhancing the Proline Effect: Pseudo-Prolines for Tayloring cis/trans Isomerization J. Am. Chem. Soc. 120, 2714-2720 (1998)
L. Henning, C. Christner, M. Kipping, B. Schelbert, P. Rücknagel, G. Küllertz & G. Fischer Selective Inactivation of Parvulin-like Peptidyl-Prolyl cis/trans Isomerization by Juglone Biochemistry (1998)
G. Küllertz, S. Lüthe & G. Fischer Semiautomated Microtiter Plate Assay for Monitoring Peptidylprolyl cis/trans Isomerase Activity in Normal and Pathological Human Sera Clinical Chemistry 44, 502-508 (1998)
110. U. Reimer, G. Scherer, M. Drewello, S. Kruber, M. Schutkowski & G. Fischer Side Chain Effects on Peptidylprolyl cis/trans Isomerization J. Mol. Biol. 279, 449-460 (1998)
C. Scholz, G. Scherer, L. M. Mayr, T. Schindler, G. Fischer & F. X. Schmid Prolyl Isomerases Do Not Catalyze Izomerization of Non-Prolyl Peptide Bonds Biol. Chem. 379, 361-365 (1998)
G. Scherer, M. L. Kramer, M. Schutkowski, U. Reimer & G. Fischer Barriers to Rotation of Secondary Amide Peptide Bonds J. Amer. Chem. Soc. 120, 5568-5574 (1998)
G. Fischer, T. Tradler & T. Zarnt The Mode of Action of Peptidyl Prolyl cis/trans Isomerases in vivo: Binding vs. Catalysis FEBS Lett. 426, 17-20 (1998)
C. Christner, G. Küllertz, G. Fischer, M. Zerlin, S. Grabley, R. Thiericke, A. Taddei & Z. Zeeck Albocycline-and Carbomycin-type Macrolides, Inhibitor of Human Prolyl Endopeptidases J. Antibiot. 51, 368-371 (1998)
C. Schiene, U. Reimer, M. Schutkowski & G. Fischer Mapping the Stereospecificity of Peptidyl Prolyl cis/trans Isomerases FEBS Lett. 432, 202-206 (1998)
O. Kops, C. Eckerskorn, S. Hottenrott, G. Fischer, H. F. Mi & M. Tropschug Ssp1, a Site-specific Parvulin Homolog from N.crassa Active in Protein Folding J. Biol. Chem. 273, 31971-31976 (1998)
J. Hani, B. Schelbert, A. Bernhardt, H. Domdey, G. Fischer, K. Wiesbauer & J.-U. Rahfeld Mutations in a Peptidylprolyl-cis/trans Isomerase Gene Lead to a Defect in 3´-End Formation of a Pre-mRNA in S. cerevisiae J. Biol. Chem. 274, 108-116 (1999)
S. A. Teter, W. A. Houry, D. Ang, T. Tradler, D. Rockabrand, G. Fischer, P. Blum, C. Georgopoulos & F. U. Hartl Polypeptide Flux through Bacterial Hsp70: DnaK Cooperates with Trigger Factor in Chaperoning Nascent Chains Cell 97, 755-765 (1999)
T. Uchida, F. Fujimori, T. Tradler, G. Fischer & J.-U. Rahfeld Identification and Characterization of a 14 kDa Human Protein as a Novel Parvulin-like Peptidyl Prolyl cis/trans Isomerase FEBS Lett. 446, 278-282 (1999)
120. R. Golbik, G. Fischer & A. Fersht Folding of Barstar C40A, C82A, P37A nd Catalysis of Peptidyl Prolyl cis/trans Isomerization by Human Cytosolic Cyclophilin (Cyp18) Protein Sci. 8, 1505-1514 (1999)
G. Küllertz, A. Liebau, P. Rücknagel, A. Schierhorn, B. Dietrich, G. Fischer & M. Luckner Stress-induced Expression of Cyclophilins in Proembryonic Masses of D. lanata does not Protect Against Freezuing/Thawing Stress Planta 208, 599-605 (1999)
C. Christner, R. Wyrwa, S. Marsch, G. Küllertz, R. Thiericke, S. Grabley, D. Schumann & G. Fischer Synthesis and Cytotoxic Evaluation of Cycloheximide Derivatives as Potential Inhibitors of FKBP12 with Neuroregenerative Properties J. Med. Chem. 42, 3615-3622 (1999)
D. Wildemann, M. Drewello, G. Fischer & M. Schutkowski Extremely Selective Mg(ClO4)2 mediated Removal of Bpoc/Ddz Moieties Suitable for the Solid Phase Synthesis of Thioxo Peptides J. Chem. Soc., Chem. Commun, 1809-1810 (1999)
M. Brandsch, I. Knutter, F. Thunecke, B. Hartrodt, I. Born, V. Börner, G. Fischer & K. Neubert Decisive Structural Determinants for the Interaction of Proline Derivates with the Intestinal H+/Peptide Symporter Eur. J. Biochem. 266, 502-508 (1999)
G. Fischer Chemical Aspects of Peptide Bond Isomerization Chem. Soc. Rev 29, 119-127 (2000)
R. Frank, M. Jakob, F. Thunecke, G. Fischer & M. Schutkowski Thioxylation as One-atom Substitution Generates a Photoswitchable Element within the Peptide Backbone Angew. Chem. Int. Ed. 39 1120-1122 (2000)
G. Fischer & C. Schiene Enzymes that Catalyze Restructuring of Proteins Curr. Opin. Struct. Biol. 10, 40-45 (2000)
A. Navarrete Santos, S. Körber, G. Küllertz, G. Fischer & B. Fischer Oxygen Stress Increases Prolyl cis/trans Isomerase Activity and Expression of Cyclophilin 18 in Rabbit Blastocytes Biol. Reprod. 62,1-7 (2000)
T. Herdegen, G. Fischer & B. G. Gold Immunophilin ligands as a Novel Treatment for Neurological Disorders Trends Pharmacol. Sci. 21, 3-5 (2000)
130. K. Piechaczek, U. Dobrindt, A. Schierhorn, G. Fischer, M. Hecker & J. Hacker Influence of Pathogenicity Islands and the Minor leuX-encoded tRNA5Leu on the Proteome Pattern of the Uropathogenic E. coli Strain 536 Int. Med. Microbiol. 290, 75-84 (2000)
E. Sekerina, J. U. Rahfeld, J. Müller, J. Fanghänel, C. Rascher, G. Fischer & P. Bayer NMR Solution Structure of hPar14 Reveals Similarity to the Peptidyl Prolyl cis/trans Isomerase Domain of the Mitotic
Regulator hPin1 but Indicates a Different Functionality of the Protein J. Mol. Biol. 301, 1003-1017 (2000)
M. Weiwad, G. Küllertz, M. Schutkowski & G. Fischer Evidence that the Substrate Backbone Conformation is Critical to Phosphorylation by p42 MAP Kinase FEBS Lett. 478, 39-42 (2000)
X. Z. Zhou, O. Kops, A. Werner, P.-J. Lu, M. Shen, G. Stoller, G. Küllertz, M. Stark, G. Fischer & K. P. Lu Pin1 ependent Prolyl Isomerization Regulates Dephosphorylation of Cdc25C and Tau Protein Mol. Cell 6 873-883 (2000)
G. C. Huang, Z. Y. Li, J. M. Zhou & G. Fischer Assisted folding of D-glyceraldehyde-3-phosphate dehydrogenase by trigger factor Protein Sci. 9, 1254-1261 (2000)
U. Dobrindt, B. Janke K. Piechaczek G. Nagy, W. Ziebuhr, G. Fischer, A. Schierhorn, A. M. Hecker, G. Blum-Oehler & J. Hacker Toxin Genes on Pathogenicity Islands: Impact for Microbial Evolution Source Int. J. Med. Microbiol. 290, 307-311 (2000)
M. Metzner, G. Stoller, K. P. Rücknagel, K. P. Lu, G. Fischer, M. Luckner & G. Küllertz Functional Replacement of the Essential ESS1 in Yeast by the Plant Parvulin DLPar13 J. Biol. Chem. 276, 13524-13529 (2001)
C. Schiene-Fischer & G. Fischer Direct Measurement Indicates Slow cis/trans Isomerization at the Secondary Amide Peptide Bond of Glycylglycine J. Amer. Chem. Soc. 123, 6227-6231 (2001)
G. Pappenberger, H. Aygün, J. W. Engels, U. Reimer, G. Fischer & T. Kiefhaber Nonprolyl cis Peptide Bonds in Unfolded Proteins Cause Complex Folding Kinetics Nat. Struct. Biol. 8, 452-458 (2001)
M. Kipping, T. Zarnt, S. Kießig, U. Reimer, G. Fischer & P. Bayer Increased Backbone Flexibility in Threonine45 Phosphorylated Hirudin Upon pH Change Biochemistry 40, 7957-7963 (2001)
140. C. Christner, T. Herdegen & G. Fischer FKBP Ligands as Novel Therapeutics for Neurological Disorder Mini Rev. Med. Chem. 1, 377-379 (2001)
A. Ribold-Tunicliffe, B. König, S. Jessen, M. S. Weiss, J. Rahfeld, J. Hacker, G. Fischer & R. Hilgenfeld Crystal Structure of Mip, a Prolylisomerase from Legionella pneumophila Nat. Struct. Biol. 8, 779-784 (2001)
A. Klettner, R. Baumgrass, Y. Zhang, G. Fischer, E. Bürger,T. Herdegen & K. Mielke The Neuroprotective Actions of FKBP Ligands: Neuronal Survival is Triggered by de novo RNA synthesis, but is Independent of Inhibition JNK and Calcineurin Mol. Brain Res. 97, 21-31 (2001)
R. Baumgraß, M. Weiwad, F. Erdmann, J. O. Liu, D. Wunderlich, S. Grabley & G. Fischer Reversible Inhibition of Calcineurin by the Polyphenolic Aldehyde Gossypol J. Biol. Chem. 276, 47914-47921 (2001)
U. Reimer & G. Fischer Local Structural Changes Caused by Peptidyl Prolyl cis/trans Isomerization in the Native State of Proteins Biophys. Chem. 96, 203-212 (2002)
C. Schiene-Fischer, J. Habazettl, F. X. Schmid & G. Fischer The hsp70 Chaperone DnaK is a Secondary Amide Peptide Bond cis/trans Isomerase Nat. Struct. Biol. 9, 419-423 (2002) (Cover feature)
C. Schiene-Fischer, J. Habazettl, T. Tradler & G. Fischer Evaluation of Similarities in the cis/trans Isomerase Function of Trigger Factor and DnaK Biol. Chem. 383, 1865-1873 (2002) (Paper of the Year 2002)
T. A. Surmacz, E. Sekerina, J. U. Rahfeld, G. Fischer & P. Bayer The N-terminal Basic Domain of Human Parvulin hPar14 is Responsible for the Entry to the Nucleus and High-affinity DNA Binding J. Mol. Biol. 321, 235-247 (2002)
Y. Zhang, S. Füssel, U. Reimer, M. Schutkowski & G. Fischer Substrate-based Design of Reversible Pin1 Inhibitors Biochemistry 41, 11868-11877 (2002)
L. Cavarec, T. Kamphausen, B. Dubourg, I. Callebaut, F. Lemeunier, D. Metivier, J. Feunteun, G. Fischer & N. Modjtahedi Identification and Characterization of Moca-cyp: a Drosophila melanogaster Nuclear Cyclophilin J. Biol. Chem. 25, 41171-41182 (2002)
150. J. Fanghänel & G. Fischer Thermodynamic Characterization of the Interaction of Human Cyclophilin 18 with Cyclosporin A Biophys. Chem. 100, 351-366 (2003)
J. H. Helbig, H. Knospe, B. Bubert, C. Yu, C. P.Lück, A. Riboldi-Tunicliffe, R. Hilgenfeld, E. Jacobs, J. Hacker, B. König & G. Fischer The PPIase Active Site of Legionella pneumophila Mip Protein
is Involved in the Infection of Eukaryotic Host Cells Biol. Chem. 384, 125-137 (2003)
G. Fischer & T. Aumüller Regulation of Peptide Bond cis/trans Isomerization by Enzyme Catalysis and its Implications in Physiological Processes Rev. Physiol. Biochem. Pharmacol. 148, 105-150 (2003)
G. Blaha , D. N. Wilson, G. Stoller, G. Fischer, R. Willumeit & K. H. Nierhaus Localization of the Trigger Factor Binding Site on the Ribosomal 50S Subunit J. Mol. Biol. 326, 887-897 (2003)
T. Reimer, M. Weiwad, A. Schierhorn, P.-K. Ruecknagel, J.-U. Rahfeld, P. Bayer & G. Fischer Phosphorylation of the N-terminal Domain Regulates Subcellular Localization and DNA-binding Properties of the Peptidyl-Prolyl cis/trans Isomerase hPar14 J. Mol. Biol. 330, 955-965 (2003)
R. Köhler, J. Fanghänel, B. König, E. Luneberg, M. Frosch, J. U. Rahfeld, R. Hilgenfeld, G. Fischer, J. Hacker & M. Steinert Biochemical and functional analyses of the Mip protein: Influence of the N-terminal half and of peptidylprolyl isomerase activity on the virulence of Legionella Infect. Immun. 71, 4389-4397 (2003)
S. Brecht, K. Schwarze, V. Waetzig, C. Christner, S. Heiland, G. Fischer, K. Sartor & T. Herdegen Changes in Peptidyl Prolyl cis/trans Isomerase Activity and Fk506 binding Protein Expression Following Neuroprotection by Fk506 in the Ischemic Rat Brain Neuroscience 120, 1037-1048 (2003)
R. Baumgraß, Y. Zhang, F. Erdmann, A. Thiel, M. Weiwad, A. Radbruch & G. Fischer Substitutions in Position 3 of Cyclosporin A Abolishes the Cyclophilin-mediated Gain-of-function Mechanism but not Immunosuppression J. Biol. Chem. 279, 2470-2479 (2004)
M. Weiwad, A. Werner, P. Rücknagel, A. Schierhorn, G. Küllertz & G. Fischer Catalysis of Proline-directed Protein Phosphorylation by Peptidyl-Prolyl cis/trans Isomerases J. Mol. Biol. 339, 635-646 (2004)
B. Dubourg, T. Kamphausen, M. Weiwad, G. Jahreis, J. Feunteun, G. Fischer & N. Modjtahedi The Human Nuclear SR-Cyp Is a Cell-cycle Regulated Cyclophilin J. Biol. Chem. 279, 23322-22330 (2004)
160. Y. Zhang, R. Baumgraß, M. Schutkowski & G. Fischer Branches on the -C Atom of Cyclosporin A Residue 3 Result in Direct Calcineurin Inhibition and Fast Cyclophilin 18 Binding Chembiochem 5, 1006-1009 (2004)
A. Kühlewein, G. Voll, B. Hernandez Alvarez, H. Kessler, G. Fischer, J.-U. Rahfeld & G. Gemmecker The Solution Structure of Escherichia coli Par10: Prototypic Member of the Parvulin Family of Peptidyl Prolyl cis/transIsomerases Protein Sci. 13, 2378-2387 (2004)
J. Fanghänel & G. Fischer Insights into the Catalytic Mechanism of Peptidyl Prolyl cis/trans Isomerases Frontiers Biosci. 9, 4553-4587 (2004)
A. Manteca, T. Kamphausen, J. Fanghänel, G. Fischer & J. Sanchez Cloning and Characterization of a Streptomyces antibioticus ATCC11891 Cyclophilin Related to Gram Negative Bacteria Cyclophilins FEBS Lett. 572, 19-26 (2004)
S. Watanabe, S. Tsuruoka, S. Vijayakumar, G. Fischer, Y. Zhang, A. Fujimura, Q. Al-Awqati & G. J. Schwartz Cyclosporin A Produces Distal Renal Tubular Acidosis by Blocking Peptidyl Prolyl cis/trans Isomerase Activity of Cyclophilin Amer. J. Physiol. 288, F40-F47 (2005)
Y. Zhang, F. Erdmann, R. Baumgrass, M. Schutkowski & G. Fischer Unexpected Side Chain Effects at Residue 8 of Cyclosporin A Derivatives Allow Photoswitching of Immunosuppression J. Biol. Chem. 280, 4842-4850 (2005)
M. Weiwad, F. Edlich, F. Erdmann, F. Jarczowski, S. Kilka, M. Dorn, A. Pechstein & G. Fischer A Reassessment of the Inhibitory Capacity of FKBP38 on Calcineurin FEBS Lett. 579, 1591-1596 (2005)
C. Yu, M. Malesevic, G. Jahreis, M. Schutkowski, G. Fischer & C. Schiene-Fischer Revealing the Architecture of Protein-Ligand Binding Sites with Template-Assisted Intramolecular Peptide-Peptide Interactions Angew. Chem. Int. Ed. 44, 1408-1412 (2005)
M. Horstmann, T. Kamphausen, K. Schweimer, M. Steinert, J. Hacker, A. Haase, P. Rösch, G. Fischer & C. Faber 1H, 13C, 15N Backbone and Side Chain Resonance Assignment of Mip 77-213 the PPIase Domain of Legionella pneumophila Mip Protein Protein Sci. 31, 77-78 (2005)
F. Edlich, M. Weiwad, F. Erdmann, J. Fanghänel, F. Jarczowski, J.-U. Rahfeld & G. Fischer Bcl-2 Regulator FKBP38 is Activated by Ca2+/Calmodulin EMBO J. 24, 2688-2699 (2005)
170. H. Satzger, C. Root, P. Gilch, W. Zinth, D. Wildemann & G. Fischer Photoswitchable Elements within a Peptide Backbone- Ultrafast Spectroscopy of Thioxylated Amides J. Phys. Chem. B 109, 4770-4775 (2005)
R. Leuzzi, L. Serino, M. Scraselli, S. Savino, M. R. Fontana, E. Monaci, A. Taddei, G. Fischer, R. Rappuoli & M. Pizza Ng-MIP, a Surface Exposed Lipoprotein of Neisseria gonorrhoeae, has a cis/trans Peptidyl Prolyl isomerase (PPIase) Activity and is Involved in Persistence in Macrophages Mol. Microbiol. 58, 669-681 (2005)
F. Eckerdt, J. Yuan, K. Saxena, B. Martin, S. Kappel, C. Lindenau, A. Kramer, S. Naumann, S. Daum, G. Fischer, I. Dikic, M. Kaufmann & K. Strebhardt Polo-like Kinase 1 Mediated Phosphorylation of Pin1 Stabilizes Pin1 by Inhibiting its Ubiquitination in Human Cells J. Biol. Chem. 44, 36575-36583 (2005)
M. Maestre-Martinez, F. Edlich, F. Jarczowski, M. Weiwad, G. Fischer & C. Lücke NMR Structure Note: hFKBP38D, the Fk506 Binding Domain of Human FKBP38 J. Biomol. NMR 34, 197-202 (2006)
D. Wildemann, F. Erdmann, B. Hernandez Alvarez, G. Stoller, X. Z. Zhou, J. Fanghänel, M. Schutkowski, K. P. Lu & G. Fischer Nanomolar Inhibitors of the Peptidyl Prolyl cis/trans Isomerase Pin1 by Screening of a Combinatorial Peptide Library J. Med. Chem. 49, 2147-2150 (2006)
F. Edlich, M. Weiwad, D. Wildemann, F. Jarczowski, S. Kilka, M.-C. Moutty, G. Jahreis, C. Lücke, W. Schmidt, F. Striggow & G. Fischer The Specific FKBP38 inhibitor N-(N’,N’-dimethylcarboxamido-methyl)-cycloheximide has Potent Neurotrophic Properties in an Ischemia Model J. Biol. Chem. 281, 14961-14970 (2006) (Paper of the Week, News article, Cover Feature)
J. Fanghänel, S. Wawra, C. Lücke, D. Wildemann & G. Fischer Isothermal Calorimetry as a New Tool to Investigate Slow Conformational Changes in Proteins and Peptides Anal. Chem. 78, 4517-4523 (2006)
S. Daum, F. Erdmann, G. Fischer, B. Féaux de Lacroix, A. Hessamian-Alinejad, S. Houben, W. Frank & M. Braun Aryl Indanyl Ketones: Efficient Inhibitors of the Human Peptidyl Prolyl cis/trans Isomerase Pin1 Angew. Chem. Int. Ed. 45, 7454-7458 (2006)
S. Wawra & G. Fischer Polypeptide Binding Proteins: What Remains to be Discovered? Mol. Microbiol. 61, 1388-1396 (2006)
M. Weiwad, F. Edlich, S. Kilka, F. Erdmann, F. Jarczowski, M. Dorn, M.-C. Moutty & G. Fischer Comparative analysis of calcineurin inhibition by complexes of immunosuppressive drugs with human FK506 binding proteins Biochemistry 45, 15776-15784 (2006)
180. M. Horstmann, P. Ehses, K. Schweimer, M. Steinert, T. Kamphausen, G. Fischer, J. Hacker, P. Rösch & C. Faber Domain Motion of the Mip Protein from Legionella pneumophila Biochemistry 45, 12303-12311 (2006)
F. Erdmann & G. Fischer The Nickel-regulated Peptidyl Prolyl cis/trans Isomerase SlyD Met. Ions Life. Sci. 2 501-528 (2007)
F. Edlich, F. Jarczowski, F. Erdmann, M.-C. Moutty, M. Weiwad & G. Fischer Calmodulin/Ca2+-mediated interaction of FKBP38 of SHP90 regulates apoptosis in neuronal cells J. Biol. Chem. 282, 15341-15348 (2007)
C. Wagner, A. Salam Khan, T. Kamphausen, B. Schmausser, U. Lorenz, G. Fischer, J. Hacker & M. Steinert Collagen binding of Mip enables Legionella pneumophila to transmigrate through the lung epithelial barrier Cell. Microbiol. 9, 450-462 (2007)
D. Wildemann, C. Schiene-Fischer, T. Aumüller, A. Bachmann, T. Kiefhaber, C. Lücke & G. Fischer A Nearly Isosteric Photosensitive Amide-Backbone Substitution Allows Enzyme Activity Switching in Ribonuclease S J. Am. Chem. Soc. 129, 4910-4918 (2007)
D. Wildemann, B. Hernandez Alvarez, G. Stoller, X. Z. Zhou, K. P. Lu, F. Erdmann & G. Fischer Specific Pin1 Inhibitors Reveal an Essential Role of Pin1 in Development of Xenopus laevis Embryos Biol. Chem. 388, 1103-1111 (2007)
M. Sieber, M. Karanik, C. Brandt, C. Blex, M. Podtschaske, F. Erdmann, R. Rost. E. Serfling, J. Liebscher, M. Pätzel, A. Radbruch, G. Fischer & R. Baumgraß Inhibition of Calicneurin-NFAT Signaling by the Pyroazolopyrimidine Compound NCI3 Eur. J. Immunol. 37, 2617-2626 (2007)
Y. Zhang, S. Daum, D. Wildemann, X. Z. Zhou, M. A. Verdecia, M. E. Bowman, C. Lücke, T. Hunter, K. P. Lu, G. Fischer & J. P. Noel Structural Basis for High-Affinity Peptide Inhibition of Human Pin1 ACS Chemical Biology 2, 320-328 (2007)
R. Siegrist, M. Zürcher, C. Baumgartner, P. Seiler, F. Diederich, S. Daum, G. Fischer, C. Klein, M. Dangl, & M. Schwaiger A Novel Synthesis of Highly Substituted Perhydropyrrolizines, Perhydroindolizines and Pyrrolidines; Inhibition of the Peptidyl-Prolyl cis/trans Isomerase (PPIase) Pin1 Helv. Chim. Acta 90, 217-259 (2007)
F. Edlich, M. Maestre Martinez, F. Jarczowski, M. Weiwad, M.-C. Moutty, M. Malešević, G. Jahreis, G. Fischer & C. Lücke A Novel Calmodulin/Ca2+ Target Recognition Activates the Bcl-2 Regulator FKBP38 J. Biol. Chem. 282, 36496-36504 (2007)
190. F. Erdmann, F. Jarczowski, M. Weiwad, G. Fischer & F. Edlich Hsp90-mediated Inhibition of FKBP38 Regulates Apoptosis in Neuroblastoma Cells FEBS Lett. 581, 5709-5714 (2007)
M. Malešević, G. Jahreis, S. Wawra, G. Fischer & C. Lücke Conformational Consequences of Regio and Stereo Selective Disulfide Bridge Oxidation in a Cyclic Peptide Chembiochem 9, 46-49 (2008)
T. Aumüller & G. Fischer Bioactivity of Folding Intermediates Studied by the Recovery of Enzymatic Activity during Refolding J. Mol. Biol. 376, 1478-1492 (2008)
F. Jarczowski, G. Fischer & F. Edlich FKBP36 forms complexes with clathrin and Hsp72 in spermatocytes. Biochemistry 47, 6946-6952( 2008)
A. Reiner, D. Wildemann, G. Fischer & T. Kiefhaber, Effect of Thioxopeptide Bonds on alpha-Helix Structures and Stability. J. Amer. Chem. Soc. 130, 8079-8084 (2008)
K. Peisker, D. Braun, T. Wölfle, J. Hentschel, U. Fünfschilling, G. Fischer, A. Sickmann & S. Rospert
Ribosome-associated Complex Binds to Ribosomes in Close Proximity of Rpl31 at the Exit of the Polypeptide Tunnel in Yeast. Mol. Biol. Cell 19, 5278-5288 (2008)
M. Braun, A. Hessamian-Alinejad, B. F. de Lacroix, B. H. Alvarez & G. Fischer Novel spiroannulated 3-benzofuranones. Synthesis and inhibition of the human peptidyl prolyl cis/trans isomerase Pin1. Molecules. 13, 995-1003 (2008).
F. Jarczowski, G. Jahreis, F. Erdmann, A. Schierhorn, G. Fischer & F. Edlich FKBP36 is an inherent multi-functional glyceraldehyde-3-phosphate dehydrogenase inhibitor. J. Biol. Chem. 284, 766-773 (2009)
K. Bauer, A. K. Kretzschmar, H. Cvijic, C. Blumert, D. Löffler, K. Brocke-Heidrich, C. Schiene-Fischer, G. Fischer, A. Sinz, C. V. Clevenger & F. Horn Cyclophilins contribute to Stat3 signaling and survival of multiple myeloma cells. Oncogene, 28, 2784-2795 (2009)
K. Uhlenbrock , M. Weiwad, R. Wetzker, G. Fischer, A. Wittinghofer & I. Rubio Reassessment of the role of FKBP38 in the Rheb/mTORC1 pathway.FEBS Lett. 583, 965-970 (2009)
200. S. Kilka,F. Erdmann, A. Migdoll, G. Fischer & M. Weiwad The Proline-Rich N-Terminal Sequence of Calcineurin A beta Determines Substrate Binding.Biochemistry 48, 1900-1910 (2009)
N.N. Barak, P. Neumann , M Sevvana, M. Schutkowski, K. Naumann, M. Malesevic, H. Reichardt & G. Fischer, M. T. Stubbs, & D. M. Ferrari Crystal Structure and Functional Analysis of the Protein Disulfide Isomerase-Related Protein ERp29. J. Mol. Biol. 385, 1630-1642 (2009)
Y. Zhang, F. Erdmann & G. Fischer Photoswitching with Protein Borrowing Modulates Affinity. Nat. Chem. Biol .5, 224-226 (2009) Cover Feature
A. Thiele, J. Zerweck, M. Weiwad, G. Fischer & M. Schutkowski High-density Peptide Microarrays for Reliable Identification of Phosphorylation Sites and Upstream Kinases. Methods Mol. Biol. 570, 203-219 (2009)
G. Zoldak, T. Aumüller, C. Lücke, J. Hritz, C. Oostenbrink, G. Fischer & F. X. Schmid A Library of Fluorescent Peptides for Exploring the Substrate Specificities of Prolyl Isomerases. Biochemistry 48, 10423-10436 (2009)
F. Erdmann, M. Weiwad , S. Kilka, M. Karanik, M. Paetzel, R. Baumgrass, J. Liebscher & G. Fischer The novel calcineurin inhibitor CN585 has potent immunosuppressive properties in stimulated human T cells. J. Biol. Chem. 285, 1888-1898 (2010)
M. Malesević, J. Kühling, F. Erdmann, M. A. Balsley, M. I. Bukrinsky, S. L. Constant, & G. Fischer A cyclosporin derivative discriminates between extracellular and intracellular cyclophilins. Angew. Chem. Int Ed Engl , 49, 213-215 (2010)
T. Aumüller, G. Jahreis, G. Fischer & C. Schiene-Fischer The Role of Prolyl cis/trans Isomers in the
Cyclophilin Assisted P. syringae AvrRpt2 Protease Activation. Biochemistry (2010)
S. Hopkins, B. Scorneaux, Z. Huang, M. G. Murray, S. Wring, C. Smitley, R. Harris, F. Erdmann, G. Fischer & Y. Ribeill SCY-635: A Novel Non-immunosuppressive Analog of Cyclosporin A that Exhibits Potent Inhibition of Hepatitis C Virus RNA Replication in vitro. Antimicrob Agents Chemother (2010)
Bücher und Monographien:
G. Küllertz, G. Fischer & A. Barth (Eds.), Dipeptidyl-peptidase IV - Biochemie,Physiologie und Pathobiochemie, Institut für Wirkstofforschung Berlin -Friedrichsfelde, 223 Seiten (1986)
G. Fischer in Struktur-Funktions-Beziehungen in Proteasen und ausgewählten Proteinen, A. Schellenberger & H.-R.Schütte, (Eds.), Verlag der Wissenschaften, Berlin, 25-50 und 153-160 (1985)
G. Fischer in Enzyme Mechanisms, M. Page & A. Williams (Eds.), Royal Society of Chemistry Publ. London, 228-240 (1987)
G. Fischer in TPP Biochemistry Presteady-state-Kinetics in Proteolytic Reactions TPP Biochemistry, 123-128 (1988)
G. Fischer in Enzymkatalyse, (Hsg. A. Schellenberger) Gustav Fischer Verlag Jena,12-71 (1989)
G. Fischer Langsame Konformationsänderungen und enzymatische Katalyse bei der Faltung von Proteinen, Jahrbuch Biotechnologie 4. Ausgabe P. Präve (Ed.), 33-57 (1992)
G. Fischer „Slow Conformational Changes and their Enzymology Nova Acta Leopoldina NF 69, 35-53(1989)
G. Fischer Das Rätsel der Faltung Chemie heute 1991/1992, 29-31
G. Fischer Faltung der Proteine:Der Weg vom Baustein zur Funktion Verh. Ges. dt. Naturf. 117, 245-260 (1992)
G. Fischer Enzymkatalyse bei Konformerenumwandlungen Nachr.Chem.Tech.Lab. 42, 987-995(1994)
G. Fischer Molekülkonformation und biologisches Signal Nova Acta Leopold.NF 72, 221-236 (1995)
G. Fischer Die Dominanz der äußeren Form in der Biochemie, Futura 8, 216-221(1994)
G. Fischer in 45 Jahre Fonds der chemischen Industrie, VCI Frankfurt/Main (Ed.), 23-32 (1995)
G. Fischer Prolyl cis/trans Isomerases-Folding Helper Enzymes, Biol.Chem. Hoppe-Seyler 376, S96 (1995)
G. Fischer Peptidyl-Prolyl cis/trans Isomerasen:Prolinspezifische Bindeproteine oder Faltungskatalysatoren, Biospektrum 2, 43-47 (1996)
G. Fischer & J.-U. Rahfeld in Guidebook to Molecular Chaperaones and Protein Folding Catalysts, M.-J. Gething (Ed.), Oxford University Press, Oxford, 399-402 & 434-435 (1997)
R. Moerschell, O. Kandor, A. L. Goldberg, G. Fischer & J.-U. Rahfeld in Guidebook to Molecular Chaperaones and Protein Folding Catalysts, M.-J. Gething (Ed.), Oxford University Press, Oxford,404-407 (1997)
G. Fischer in Drug Discovery from Nature, S. Grabley & R. Thiericke (Eds.), Springer-Verlag Berlin, Heidelberg, New York, 157-181 (1999)
G. Fischer & F. X. Schmid in Molecular Chaperones and Folding Catalysts, B. Buckau (Ed.), Harwood Academic Publishers, Amsterdam, 461-491 (1999)
G. Fischer in Enzyclopedia of Molecular Biology, T. E. Creighton (Ed.), J. Wiley & Sons, Inc. New York, 470-471, 599-602, 918, 1814-1815, 2099-2100 (1999)
G. Fischer in Immunophilins in the Brain, B. G. Gold, G. Fischer & T. Herdegen (Eds)., Prous Science, Barcelona, 282 pp (2000)
G. Fischer in Handbook of Protein Folding, J. Buchner & T. Kiefhaber, (Eds.), Wiley-VCH Verlag, Weinheim, 377-401 (2005)
F. Edlich & G. Fischer in Molecular Chaperones in Health and Diseases, M. Gaestel (Ed.), Springer-Verlag Berlin, 359-405 (2006)
G. Fischer & S. Wawra in Cis/trans Isomerization in Biochemistry, C. Dugave (Ed.), Wiley-VCH Verlag, Weinheim, 167-225 (2006)